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Last update : Wed 22 May 2024
TOP
Cidofovir
Short name: CDV
Chembl ID:
CHEMBL152
SMILES (Simplified Molecular Input Line Entry System): C1=CN(C(=O)N=C1N)CC(CO)OCP(=O)(O)O
Assays:
Filter:
Mutant
Gene
Type
Virus
EC50 ratio
Phenotype
Assay
Reference
Q229K
UL54
SNP
Human betaherpesvirus 5
1.00
No resistance
Details
Phenotypic evaluation of previously uncharacterized cytomegalovirus DNA polymerase sequence variants detected in a valganciclovir treatment trial. (Apr 2014)
D247N
UL54
SNP
Human betaherpesvirus 5
0.90
No resistance
Details
Phenotypic evaluation of previously uncharacterized cytomegalovirus DNA polymerase sequence variants detected in a valganciclovir treatment trial. (Apr 2014)
D262N
UL54
SNP
Human betaherpesvirus 5
1.00
No resistance
Details
Phenotypic evaluation of previously uncharacterized cytomegalovirus DNA polymerase sequence variants detected in a valganciclovir treatment trial. (Apr 2014)
D271A
UL54
SNP
Human betaherpesvirus 5
1.10
No resistance
Details
Phenotypic evaluation of previously uncharacterized cytomegalovirus DNA polymerase sequence variants detected in a valganciclovir treatment trial. (Apr 2014)
D288N
UL54
SNP
Human betaherpesvirus 5
1.20
No resistance
Details
Phenotypic evaluation of previously uncharacterized cytomegalovirus DNA polymerase sequence variants detected in a valganciclovir treatment trial. (Apr 2014)
D301N
UL54
SNP
Human betaherpesvirus 5
3.00
Intermediate level resistance
Details
Viral DNA polymerase mutations associated with drug resistance in human cytomegalovirus. (Jul 2003)
E303G
UL54
SNP
Human betaherpesvirus 5
20.00
High level resistance
Details
Novel Cytomegalovirus UL54 DNA Polymerase Gene Mutations Selected In Vitro That Confer Brincidofovir Resistance. (Jun 2016)
E303D
UL54
SNP
Human betaherpesvirus 5
16.00
High level resistance
Details
Novel Cytomegalovirus UL54 DNA Polymerase Gene Mutations Selected In Vitro That Confer Brincidofovir Resistance. (Jun 2016)
F396L
UL54
SNP
Human betaherpesvirus 5
1.50
No resistance
Details
Phenotypic evaluation of previously uncharacterized cytomegalovirus DNA polymerase sequence variants detected in a valganciclovir treatment trial. (Apr 2014)
N408H
UL54
SNP
Human betaherpesvirus 5
3.30
Intermediate level resistance
Details
Drug Resistance Assessed in a Phase 3 Clinical Trial of Maribavir Therapy for Refractory or Resistant Cytomegalovirus Infection in Transplant Recipients. (Feb 2024)
N408D
UL54
SNP
Human betaherpesvirus 5
5.60
High level resistance
Details
Characterization of drug resistance-associated mutations in the human cytomegalovirus DNA polymerase gene by using recombinant mutant viruses generated from overlapping DNA fragments. (Jul 1998)
N408K
UL54
SNP
Human betaherpesvirus 5
21.00
High level resistance
Details
Multidrug resistance conferred by novel DNA polymerase mutations in human cytomegalovirus isolates. (Jan 2007)
N408S
UL54
SNP
Human betaherpesvirus 5
7.50
High level resistance
Details
Novel DNA polymerase mutations conferring cytomegalovirus resistance: input of BAC-recombinant phenotyping and 3D model. (Apr 2013)
N410K
UL54
SNP
Human betaherpesvirus 5
3.00
Intermediate level resistance
Details
Viral DNA polymerase mutations associated with drug resistance in human cytomegalovirus. (Jul 2003)
F412C
UL54
SNP
Human betaherpesvirus 5
18.00
High level resistance
Details
Evolution of mutations conferring multidrug resistance during prophylaxis and therapy for cytomegalovirus disease. (Sep 1997)
F412L
UL54
SNP
Human betaherpesvirus 5
9.40
High level resistance
Details
Phenotypic diversity of cytomegalovirus DNA polymerase gene variants observed after antiviral therapy. (Apr 2011)
F412S
UL54
SNP
Human betaherpesvirus 5
13.00
High level resistance
Details
Phenotypic diversity of cytomegalovirus DNA polymerase gene variants observed after antiviral therapy. (Apr 2011)
F412V
UL54
SNP
Human betaherpesvirus 5
15.50
High level resistance
Details
Characterization of drug resistance-associated mutations in the human cytomegalovirus DNA polymerase gene by using recombinant mutant viruses generated from overlapping DNA fragments. (Jul 1998)
D413A
UL54
SNP
Human betaherpesvirus 5
11.00
High level resistance
Details
Development of new cytomegalovirus UL97 and DNA polymerase mutations conferring drug resistance after valganciclovir therapy in allogeneic stem cell recipients. (Feb 2007)
D413E
UL54
SNP
Human betaherpesvirus 5
4.30
Intermediate level resistance
Details
Viral DNA polymerase mutations associated with drug resistance in human cytomegalovirus. (Jul 2003)
D413N
UL54
SNP
Human betaherpesvirus 5
10.00
High level resistance
Details
Improved detection of emerging drug-resistant mutant cytomegalovirus subpopulations by deep sequencing. (Aug 2014)
D413del
UL54
in/del
Human betaherpesvirus 5
5.80
High level resistance
Details
Novel Cytomegalovirus UL54 DNA Polymerase Gene Mutations Selected In Vitro That Confer Brincidofovir Resistance. (Jun 2016)
D413Y
UL54
SNP
Human betaherpesvirus 5
9.30
High level resistance
Details
Novel Cytomegalovirus UL54 DNA Polymerase Gene Mutations Selected In Vitro That Confer Brincidofovir Resistance. (Jun 2016)
L424V
UL54
SNP
Human betaherpesvirus 5
1.30
No resistance
Details
Phenotypic evaluation of previously uncharacterized cytomegalovirus DNA polymerase sequence variants detected in a valganciclovir treatment trial. (Apr 2014)
F460L
UL54
SNP
Human betaherpesvirus 5
1.20
No resistance
Details
Phenotypic evaluation of previously uncharacterized cytomegalovirus DNA polymerase sequence variants detected in a valganciclovir treatment trial. (Apr 2014)
V476G
UL54
SNP
Human betaherpesvirus 5
0.90
No resistance
Details
Phenotypic evaluation of previously uncharacterized cytomegalovirus DNA polymerase sequence variants detected in a valganciclovir treatment trial. (Apr 2014)
P488R
UL54
SNP
Human betaherpesvirus 5
7.90
High level resistance
Details
Recombinant phenotyping of cytomegalovirus UL54 mutations that emerged during cell passages in the presence of either ganciclovir or foscarnet. (Sep 2011)
A492D
UL54
SNP
Human betaherpesvirus 5
1.36
No resistance
Details
Identification of resistance-associated HCMV UL97- and UL54-mutations and a UL97-polymporphism with impact on phenotypic drug-resistance. (Jul 2016)
N495K
UL54
SNP
Human betaherpesvirus 5
1.10
No resistance
Details
A novel mutation in the UL54 gene of human cytomegalovirus isolates that confers resistance to foscarnet. ( 2006)
K500N
UL54
SNP
Human betaherpesvirus 5
3.00
Intermediate level resistance
Details
Recombinant phenotyping of cytomegalovirus UL54 mutations that emerged during cell passages in the presence of either ganciclovir or foscarnet. (Sep 2011)
L501F
UL54
SNP
Human betaherpesvirus 5
3.80
Intermediate level resistance
Details
Drug Resistance Assessed in a Phase 3 Clinical Trial of Maribavir Therapy for Refractory or Resistant Cytomegalovirus Infection in Transplant Recipients. (Feb 2024)
L501I
UL54
SNP
Human betaherpesvirus 5
9.10
High level resistance
Details
Characterization of drug resistance-associated mutations in the human cytomegalovirus DNA polymerase gene by using recombinant mutant viruses generated from overlapping DNA fragments. (Jul 1998)
T503A
UL54
SNP
Human betaherpesvirus 5
3.70
Intermediate level resistance
Details
Drug Resistance Assessed in a Phase 3 Clinical Trial of Maribavir Therapy for Refractory or Resistant Cytomegalovirus Infection in Transplant Recipients. (Feb 2024)
T503I
UL54
SNP
Human betaherpesvirus 5
6.10
High level resistance
Details
Viral DNA polymerase mutations associated with drug resistance in human cytomegalovirus. (Jul 2003)
A505V
UL54
SNP
Human betaherpesvirus 5
2.00
Low level resistance
Details
Phenotypic evaluation of previously uncharacterized cytomegalovirus DNA polymerase sequence variants detected in a valganciclovir treatment trial. (Apr 2014)
K513Q
UL54
SNP
Human betaherpesvirus 5
18.00
High level resistance
Details
Drug Resistance Assessed in a Phase 3 Clinical Trial of Maribavir Therapy for Refractory or Resistant Cytomegalovirus Infection in Transplant Recipients. (Feb 2024)
K513E
UL54
SNP
Human betaherpesvirus 5
9.10
High level resistance
Details
Characterization of drug resistance-associated mutations in the human cytomegalovirus DNA polymerase gene by using recombinant mutant viruses generated from overlapping DNA fragments. (Jul 1998)
K513N
UL54
SNP
Human betaherpesvirus 5
12.50
High level resistance
Details
A point mutation in the human cytomegalovirus DNA polymerase gene selected in vitro by cidofovir confers a slow replication phenotype in cell culture. (Sep 1998)
K513R
UL54
SNP
Human betaherpesvirus 5
10.00
High level resistance
Details
Improved detection of emerging drug-resistant mutant cytomegalovirus subpopulations by deep sequencing. (Aug 2014)
D515E
UL54
SNP
Human betaherpesvirus 5
1.60
No resistance
Details
Drug-resistant human cytomegalovirus infection in children after allogeneic stem cell transplantation may have different clinical outcomes. (Nov 2000)
D515Y
UL54
SNP
Human betaherpesvirus 5
0.87
No resistance
Details
Contrasting effect of new HCMV pUL54 mutations on antiviral drug susceptibility: Benefits and limits of 3D analysis. (May 2016)
L516R
UL54
SNP
Human betaherpesvirus 5
5.10
High level resistance
Details
Viral DNA polymerase mutations associated with drug resistance in human cytomegalovirus. (Jul 2003)
L516W
UL54
SNP
Human betaherpesvirus 5
8.49
High level resistance
Details
Identification of resistance-associated HCMV UL97- and UL54-mutations and a UL97-polymporphism with impact on phenotypic drug-resistance. (Jul 2016)
I521T
UL54
SNP
Human betaherpesvirus 5
5.10
High level resistance
Details
Contrasting drug resistance phenotypes resulting from cytomegalovirus DNA polymerase mutations at the same exonuclease locus. (Sep 2008)
P522T
UL54
SNP
Human betaherpesvirus 5
2.00
Low level resistance
Details
Drug Resistance Assessed in a Phase 3 Clinical Trial of Maribavir Therapy for Refractory or Resistant Cytomegalovirus Infection in Transplant Recipients. (Feb 2024)
P522A
UL54
SNP
Human betaherpesvirus 5
4.10
Intermediate level resistance
Details
Contrasting drug resistance phenotypes resulting from cytomegalovirus DNA polymerase mutations at the same exonuclease locus. (Sep 2008)
P522S
UL54
SNP
Human betaherpesvirus 5
3.60
Intermediate level resistance
Details
Characterization of drug resistance-associated mutations in the human cytomegalovirus DNA polymerase gene by using recombinant mutant viruses generated from overlapping DNA fragments. (Jul 1998)
C524del
UL54
in/del
Human betaherpesvirus 5
9.70
High level resistance
Details
Novel DNA polymerase mutations conferring cytomegalovirus resistance: input of BAC-recombinant phenotyping and 3D model. (Apr 2013)
V526L
UL54
SNP
Human betaherpesvirus 5
2.50
Low level resistance
Details
Characterization of multiple cytomegalovirus drug resistance mutations detected in a hematopoietic stem cell transplant recipient by recombinant phenotyping. (Nov 2014)
C539G
UL54
SNP
Human betaherpesvirus 5
4.40
Intermediate level resistance
Details
Improved detection of emerging drug-resistant mutant cytomegalovirus subpopulations by deep sequencing. (Aug 2014)
C539R
UL54
SNP
Human betaherpesvirus 5
13.30
High level resistance
Details
Recombinant phenotyping of cytomegalovirus UL54 mutations that emerged during cell passages in the presence of either ganciclovir or foscarnet. (Sep 2011)
D542E
UL54
SNP
Human betaherpesvirus 5
12.00
High level resistance
Details
Selection and recombinant phenotyping of a novel CMX001 and cidofovir resistance mutation in human cytomegalovirus. (Jul 2013)
A543S
UL54
SNP
Human betaherpesvirus 5
1.00
No resistance
Details
Phenotypic evaluation of previously uncharacterized cytomegalovirus DNA polymerase sequence variants detected in a valganciclovir treatment trial. (Apr 2014)
L545F
UL54
SNP
Human betaherpesvirus 5
11.00
High level resistance
Details
Drug Resistance Assessed in a Phase 3 Clinical Trial of Maribavir Therapy for Refractory or Resistant Cytomegalovirus Infection in Transplant Recipients. (Feb 2024)
L545S
UL54
SNP
Human betaherpesvirus 5
9.10
High level resistance
Details
Characterization of drug resistance-associated mutations in the human cytomegalovirus DNA polymerase gene by using recombinant mutant viruses generated from overlapping DNA fragments. (Jul 1998)
L545W
UL54
SNP
Human betaherpesvirus 5
6.30
High level resistance
Details
Phenotypic diversity of cytomegalovirus DNA polymerase gene variants observed after antiviral therapy. (Apr 2011)
T552N
UL54
SNP
Human betaherpesvirus 5
1.20
No resistance
Details
Recombinant phenotyping of cytomegalovirus UL54 mutations that emerged during cell passages in the presence of either ganciclovir or foscarnet. (Sep 2011)
Q578H
UL54
SNP
Human betaherpesvirus 5
2.30
Low level resistance
Details
Phenotypic diversity of cytomegalovirus DNA polymerase gene variants observed after antiviral therapy. (Apr 2011)
Q578L
UL54
SNP
Human betaherpesvirus 5
0.80
No resistance
Details
Improved detection of emerging drug-resistant mutant cytomegalovirus subpopulations by deep sequencing. (Aug 2014)
S585A
UL54
SNP
Human betaherpesvirus 5
1.40
No resistance
Details
Recombinant phenotyping of cytomegalovirus UL54 mutations that emerged during cell passages in the presence of either ganciclovir or foscarnet. (Sep 2011)
D588E
UL54
SNP
Human betaherpesvirus 5
1.10
No resistance
Details
Characterization of drug resistance-associated mutations in the human cytomegalovirus DNA polymerase gene by using recombinant mutant viruses generated from overlapping DNA fragments. (Jul 1998)
D588N
UL54
SNP
Human betaherpesvirus 5
2.70
Low level resistance
Details
How evolution of mutations conferring drug resistance affects viral dynamics and clinical outcomes of cytomegalovirus-infected hematopoietic cell transplant recipients. (Jan 2005)
C590F
UL54
SNP
Human betaherpesvirus 5
1.60
No resistance
Details
Drug Resistance Assessed in a Phase 3 Clinical Trial of Maribavir Therapy for Refractory or Resistant Cytomegalovirus Infection in Transplant Recipients. (Feb 2024)
F595I
UL54
SNP
Human betaherpesvirus 5
1.20
No resistance
Details
Recombinant phenotyping of cytomegalovirus UL54 mutations that emerged during cell passages in the presence of either ganciclovir or foscarnet. (Sep 2011)
V654G
UL54
SNP
Human betaherpesvirus 5
1.10
No resistance
Details
Phenotypic evaluation of previously uncharacterized cytomegalovirus DNA polymerase sequence variants detected in a valganciclovir treatment trial. (Apr 2014)
S660G
UL54
SNP
Human betaherpesvirus 5
0.90
No resistance
Details
Phenotypic evaluation of previously uncharacterized cytomegalovirus DNA polymerase sequence variants detected in a valganciclovir treatment trial. (Apr 2014)
G667N
UL54
SNP
Human betaherpesvirus 5
0.80
No resistance
Details
Phenotypic evaluation of previously uncharacterized cytomegalovirus DNA polymerase sequence variants detected in a valganciclovir treatment trial. (Apr 2014)
A692G
UL54
SNP
Human betaherpesvirus 5
0.90
No resistance
Details
Phenotypic evaluation of previously uncharacterized cytomegalovirus DNA polymerase sequence variants detected in a valganciclovir treatment trial. (Apr 2014)
T700A
UL54
SNP
Human betaherpesvirus 5
1.50
No resistance
Details
Characterization of drug resistance-associated mutations in the human cytomegalovirus DNA polymerase gene by using recombinant mutant viruses generated from overlapping DNA fragments. (Jul 1998)
V715A
UL54
SNP
Human betaherpesvirus 5
0.47
Possible hypersensitivity, no resistance
Details
Identification of resistance-associated HCMV UL97- and UL54-mutations and a UL97-polymporphism with impact on phenotypic drug-resistance. (Jul 2016)
V715M
UL54
SNP
Human betaherpesvirus 5
1.10
No resistance
Details
Single amino acid changes in the DNA polymerase confer foscarnet resistance and slow-growth phenotype, while mutations in the UL97-encoded phosphotransferase confer ganciclovir resistance in three double-resistant human cytomegalovirus strains recovered from patients with AIDS. (Mar 1996)
I726T
UL54
SNP
Human betaherpesvirus 5
1.70
No resistance
Details
Phenotypic evaluation of previously uncharacterized cytomegalovirus DNA polymerase sequence variants detected in a valganciclovir treatment trial. (Apr 2014)
I726V
UL54
SNP
Human betaherpesvirus 5
1.90
No resistance
Details
Phenotypic evaluation of previously uncharacterized cytomegalovirus DNA polymerase sequence variants detected in a valganciclovir treatment trial. (Apr 2014)
E756D
UL54
SNP
Human betaherpesvirus 5
0.70
No resistance
Details
Viral DNA polymerase mutations associated with drug resistance in human cytomegalovirus. (Jul 2003)
E756K
UL54
SNP
Human betaherpesvirus 5
2.20
Low level resistance
Details
Viral DNA polymerase mutations associated with drug resistance in human cytomegalovirus. (Jul 2003)
E756Q
UL54
SNP
Human betaherpesvirus 5
1.00
No resistance
Details
Mutations conferring foscarnet resistance in a cohort of patients with acquired immunodeficiency syndrome and cytomegalovirus retinitis. (Mar 2003)
L773V
UL54
SNP
Human betaherpesvirus 5
2.50
Low level resistance
Details
Improved detection of emerging drug-resistant mutant cytomegalovirus subpopulations by deep sequencing. (Aug 2014)
L776M
UL54
SNP
Human betaherpesvirus 5
1.00
No resistance
Details
Artesunate as a potent antiviral agent in a patient with late drug-resistant cytomegalovirus infection after hematopoietic stem cell transplantation. (May 2008)
V781I
UL54
SNP
Human betaherpesvirus 5
1.20
No resistance
Details
Characterization of drug resistance-associated mutations in the human cytomegalovirus DNA polymerase gene by using recombinant mutant viruses generated from overlapping DNA fragments. (Jul 1998)
V787A
UL54
SNP
Human betaherpesvirus 5
Details
Rapid detection of human cytomegalovirus UL97 and UL54 mutations for antiviral resistance in clinical specimens. (May 2013)
V787E
UL54
SNP
Human betaherpesvirus 5
2.90
Low level resistance
Details
Compartmentalization of a Multidrug-Resistant Cytomegalovirus UL54 Mutant in a Stem Cell Transplant Recipient with Encephalitis. (Sep 2019)
V787L
UL54
SNP
Human betaherpesvirus 5
1.00
No resistance
Details
Mutations conferring foscarnet resistance in a cohort of patients with acquired immunodeficiency syndrome and cytomegalovirus retinitis. (Mar 2003)
E793V
UL54
SNP
Human betaherpesvirus 5
0.70
No resistance
Details
Phenotypic evaluation of previously uncharacterized cytomegalovirus DNA polymerase sequence variants detected in a valganciclovir treatment trial. (Apr 2014)
Q795P
UL54
SNP
Human betaherpesvirus 5
0.90
No resistance
Details
Phenotypic evaluation of previously uncharacterized cytomegalovirus DNA polymerase sequence variants detected in a valganciclovir treatment trial. (Apr 2014)
Q795R
UL54
SNP
Human betaherpesvirus 5
0.90
No resistance
Details
Phenotypic evaluation of previously uncharacterized cytomegalovirus DNA polymerase sequence variants detected in a valganciclovir treatment trial. (Apr 2014)
L802M
UL54
SNP
Human betaherpesvirus 5
0.90-1.80
Range of values of No resistance
Details
Evolution of mutations conferring multidrug resistance during prophylaxis and therapy for cytomegalovirus disease. (Sep 1997)
L802V
UL54
SNP
Human betaherpesvirus 5
1.10
No resistance
Details
Recombinant phenotyping of cytomegalovirus UL54 mutations that emerged during cell passages in the presence of either ganciclovir or foscarnet. (Sep 2011)
K805Q
UL54
SNP
Human betaherpesvirus 5
2.20
Low level resistance
Details
Characterization of drug resistance-associated mutations in the human cytomegalovirus DNA polymerase gene by using recombinant mutant viruses generated from overlapping DNA fragments. (Jul 1998)
A809V
UL54
SNP
Human betaherpesvirus 5
1.70
No resistance
Details
Improved detection of emerging drug-resistant mutant cytomegalovirus subpopulations by deep sequencing. (Aug 2014)
V812L
UL54
SNP
Human betaherpesvirus 5
3.20
Intermediate level resistance
Details
A point mutation in the human cytomegalovirus DNA polymerase gene selected in vitro by cidofovir confers a slow replication phenotype in cell culture. (Sep 1998)
T813S
UL54
SNP
Human betaherpesvirus 5
2.90
Low level resistance
Details
Growth and drug resistance phenotypes resulting from cytomegalovirus DNA polymerase region III mutations observed in clinical specimens. (Nov 2007)
T821I
UL54
SNP
Human betaherpesvirus 5
1.90
No resistance
Details
Characterization of drug resistance-associated mutations in the human cytomegalovirus DNA polymerase gene by using recombinant mutant viruses generated from overlapping DNA fragments. (Jul 1998)
M827I
UL54
SNP
Human betaherpesvirus 5
0.70
No resistance
Details
Analysis of Mutations in the Gene Encoding Cytomegalovirus DNA Polymerase in a Phase 2 Clinical Trial of Brincidofovir Prophylaxis. (Jul 2016)
P829S
UL54
SNP
Human betaherpesvirus 5
1.60
No resistance
Details
Recombinant phenotyping of cytomegalovirus UL54 mutations that emerged during cell passages in the presence of either ganciclovir or foscarnet. (Sep 2011)
A834P
UL54
SNP
Human betaherpesvirus 5
3.00
Intermediate level resistance
Details
Cytomegalovirus antiviral resistance associated with treatment induced UL97 (protein kinase) and UL54 (DNA polymerase) mutations. (Sep 2004)
T838A
UL54
SNP
Human betaherpesvirus 5
0.80
No resistance
Details
How evolution of mutations conferring drug resistance affects viral dynamics and clinical outcomes of cytomegalovirus-infected hematopoietic cell transplant recipients. (Jan 2005)
G841S
UL54
SNP
Human betaherpesvirus 5
1.10
No resistance
Details
Phenotypic evaluation of previously uncharacterized cytomegalovirus DNA polymerase sequence variants detected in a valganciclovir treatment trial. (Apr 2014)
G841A
UL54
SNP
Human betaherpesvirus 5
2.60
Low level resistance
Details
Growth and drug resistance phenotypes resulting from cytomegalovirus DNA polymerase region III mutations observed in clinical specimens. (Nov 2007)
M844T
UL54
SNP
Human betaherpesvirus 5
1.30
No resistance
Details
Cyclopropavir susceptibility of cytomegalovirus DNA polymerase mutants selected after antiviral drug exposure. (Jan 2012)
M844V
UL54
SNP
Human betaherpesvirus 5
1.60
No resistance
Details
Cyclopropavir susceptibility of cytomegalovirus DNA polymerase mutants selected after antiviral drug exposure. (Jan 2012)
P859A
UL54
SNP
Human betaherpesvirus 5
1.00
No resistance
Details
Phenotypic evaluation of previously uncharacterized cytomegalovirus DNA polymerase sequence variants detected in a valganciclovir treatment trial. (Apr 2014)
L862F
UL54
SNP
Human betaherpesvirus 5
0.90
No resistance
Details
Recombinant phenotyping of cytomegalovirus UL54 mutations that emerged during cell passages in the presence of either ganciclovir or foscarnet. (Sep 2011)
V902G
UL54
SNP
Human betaherpesvirus 5
1.00
No resistance
Details
Phenotypic evaluation of previously uncharacterized cytomegalovirus DNA polymerase sequence variants detected in a valganciclovir treatment trial. (Apr 2014)
V946L
UL54
SNP
Human betaherpesvirus 5
0.90
No resistance
Details
Recombinant phenotyping of cytomegalovirus UL54 mutations that emerged during cell passages in the presence of either ganciclovir or foscarnet. (Sep 2011)
K947E
UL54
SNP
Human betaherpesvirus 5
1.00
No resistance
Details
Phenotypic evaluation of previously uncharacterized cytomegalovirus DNA polymerase sequence variants detected in a valganciclovir treatment trial. (Apr 2014)
L957F
UL54
SNP
Human betaherpesvirus 5
1.40
No resistance
Details
Recombinant phenotyping of cytomegalovirus UL54 mutations that emerged during cell passages in the presence of either ganciclovir or foscarnet. (Sep 2011)
M959T
UL54
SNP
Human betaherpesvirus 5
0.90
No resistance
Details
Phenotypic evaluation of previously uncharacterized cytomegalovirus DNA polymerase sequence variants detected in a valganciclovir treatment trial. (Apr 2014)
981-982del
UL54
in/del
Human betaherpesvirus 5
4.20
Intermediate level resistance
Details
Drug Resistance Assessed in a Phase 3 Clinical Trial of Maribavir Therapy for Refractory or Resistant Cytomegalovirus Infection in Transplant Recipients. (Feb 2024)
D981del
UL54
in/del
Human betaherpesvirus 5
2.80
Low level resistance
Details
A deletion mutation in region V of the cytomegalovirus DNA polymerase sequence confers multidrug resistance. (Dec 2000)
A987G
UL54
SNP
Human betaherpesvirus 5
11.30
High level resistance
Details
Characterization of drug resistance-associated mutations in the human cytomegalovirus DNA polymerase gene by using recombinant mutant viruses generated from overlapping DNA fragments. (Jul 1998)