CHARMD

Comprehensive Herpesviruses Antiviral drug Resistance Mutation Database


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    D515E

    Antiviral assays:

    Antiviral EC50 ratio Phenotype Strain Source Marker Assay Reference
    Ganciclovir 2.70 Low level resistance Recombinant Details Drug-resistant human cytomegalovirus infection in children after allogeneic stem cell transplantation may have different clinical outcomes. (Nov 2000)
    Cidofovir 1.60 No resistance Recombinant Details Drug-resistant human cytomegalovirus infection in children after allogeneic stem cell transplantation may have different clinical outcomes. (Nov 2000)
    Foscarnet 4.60 Intermediate level resistance Recombinant Details Drug-resistant human cytomegalovirus infection in children after allogeneic stem cell transplantation may have different clinical outcomes. (Nov 2000)
    Cidofovir 1.10 No resistance Clinical Isolate Details A new locus of foscarnet resistance in the cytomegalovirus UL54 DNA polymerase gene among uncharacterized mutations in recent clinical trials. (Feb 2026)
    Foscarnet 0.90 No resistance Clinical Isolate Details A new locus of foscarnet resistance in the cytomegalovirus UL54 DNA polymerase gene among uncharacterized mutations in recent clinical trials. (Feb 2026)
    Ganciclovir 1.00 No resistance Clinical Isolate Details A new locus of foscarnet resistance in the cytomegalovirus UL54 DNA polymerase gene among uncharacterized mutations in recent clinical trials. (Feb 2026)

    Mutations at the same locus:

    Mutant Resistances
    D515G Natural polymorphism
    D515Y Ganciclovir: High level resistance
    D515Y Cidofovir: No resistance
    D515Y Foscarnet: Intermediate level resistance
    D515Y Cidofovir: Low level resistance
    D515Y Foscarnet: No resistance
    D515Y Ganciclovir: Intermediate level resistance

    Tilloy et al., 2024
    Interdeposit Digital Number: IDDN.FR.001.420004.000.S.X.2024.000.31230