CHARMD

Comprehensive Herpesviruses Antiviral drug Resistance Mutation Database


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    L501I

    Antiviral assays:

    Antiviral EC50 ratio Phenotype Strain Source Marker Assay Reference
    Ganciclovir 6.00 High level resistance Recombinant Details Characterization of drug resistance-associated mutations in the human cytomegalovirus DNA polymerase gene by using recombinant mutant viruses generated from overlapping DNA fragments. (Jul 1998)
    Cidofovir 9.10 High level resistance Recombinant Details Characterization of drug resistance-associated mutations in the human cytomegalovirus DNA polymerase gene by using recombinant mutant viruses generated from overlapping DNA fragments. (Jul 1998)
    Foscarnet 1.40 No resistance Recombinant Details Characterization of drug resistance-associated mutations in the human cytomegalovirus DNA polymerase gene by using recombinant mutant viruses generated from overlapping DNA fragments. (Jul 1998)

    Mutations at the same locus:

    Mutant Resistances
    L501F Ganciclovir: Low level resistance
    L501F Cidofovir: Intermediate level resistance
    L501F Foscarnet: No resistance


    Tilloy et al., 2024
    Interdeposit Digital Number: IDDN.FR.001.420004.000.S.X.2024.000.31230