Herpesvirus Antiviral Resistance
Database


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    E756Q

    Antiviral assays:

    Antiviral EC50 ratio Phenotype Strain Source Marker Assay Reference
    Ganciclovir 1.70 No resistance Recombinant Details Mutations conferring foscarnet resistance in a cohort of patients with acquired immunodeficiency syndrome and cytomegalovirus retinitis. (Mar 2003)
    Cidofovir 1.00 No resistance Recombinant Details Mutations conferring foscarnet resistance in a cohort of patients with acquired immunodeficiency syndrome and cytomegalovirus retinitis. (Mar 2003)
    Foscarnet 4.30 Intermediate level resistance Recombinant Details Mutations conferring foscarnet resistance in a cohort of patients with acquired immunodeficiency syndrome and cytomegalovirus retinitis. (Mar 2003)

    Mutations at the same locus:

    Mutant Resistances
    E756D Ganciclovir: No resistance
    E756D Cidofovir: No resistance
    E756D Foscarnet: Intermediate level resistance
    E756K Ganciclovir: Low level resistance
    E756K Cidofovir: Low level resistance
    E756K Foscarnet: At least High level resistance