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Comprehensive Herpesviruses Antiviral drug Resistance Mutation Database
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Last update : Mon 20 Apr 2026
TOP
A928T
Virus:
Human betaherpesvirus 5
Gene:
UL54
Resistance summary:*
Ganciclovir:
At least Intermediate level resistance
Cidofovir:
At least Intermediate level resistance
Foscarnet:
At least Intermediate level resistance
Cidofovir:
No resistance
Foscarnet:
No resistance
Ganciclovir:
No resistance
*If there is more than one line per antiviral, please refer to the table below
Antiviral assays:
Antiviral
EC50 ratio
Phenotype
Strain
Source
Marker
Assay
Reference
Ganciclovir
>3.00
At least Intermediate level resistance
Details
Genotypic and Phenotypic Study of Antiviral Resistance Mutations in Refractory Cytomegalovirus Infection. (Nov 2022)
Cidofovir
>3.00
At least Intermediate level resistance
Details
Genotypic and Phenotypic Study of Antiviral Resistance Mutations in Refractory Cytomegalovirus Infection. (Nov 2022)
Foscarnet
>3.00
At least Intermediate level resistance
Details
Genotypic and Phenotypic Study of Antiviral Resistance Mutations in Refractory Cytomegalovirus Infection. (Nov 2022)
Cidofovir
1.00
No resistance
Clinical Isolate
Details
A new locus of foscarnet resistance in the cytomegalovirus UL54 DNA polymerase gene among uncharacterized mutations in recent clinical trials. (Feb 2026)
Foscarnet
0.90
No resistance
Clinical Isolate
Details
A new locus of foscarnet resistance in the cytomegalovirus UL54 DNA polymerase gene among uncharacterized mutations in recent clinical trials. (Feb 2026)
Ganciclovir
0.90
No resistance
Clinical Isolate
Details
A new locus of foscarnet resistance in the cytomegalovirus UL54 DNA polymerase gene among uncharacterized mutations in recent clinical trials. (Feb 2026)
Tilloy
et al.
, 2024
Interdeposit Digital Number: IDDN.FR.001.420004.000.S.X.2024.000.31230