CHARMD

Comprehensive Herpesviruses Antiviral drug Resistance Mutation Database


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    T552N

    Antiviral assays:

    Antiviral EC50 ratio Phenotype Strain Source Marker Assay Reference
    Ganciclovir 1.90 No resistance Recombinant Details Recombinant phenotyping of cytomegalovirus UL54 mutations that emerged during cell passages in the presence of either ganciclovir or foscarnet. (Sep 2011)
    Cidofovir 1.20 No resistance Recombinant Details Recombinant phenotyping of cytomegalovirus UL54 mutations that emerged during cell passages in the presence of either ganciclovir or foscarnet. (Sep 2011)
    Foscarnet 2.60 Low level resistance Recombinant Details Recombinant phenotyping of cytomegalovirus UL54 mutations that emerged during cell passages in the presence of either ganciclovir or foscarnet. (Sep 2011)
    Cidofovir 1.00 No resistance Laboratory strain Details Foscarnet resistance mutations mapping to atypical domains of the cytomegalovirus DNA polymerase gene. (Feb 2017)
    Cidofovir 1.70 No resistance Laboratory strain Details Foscarnet resistance mutations mapping to atypical domains of the cytomegalovirus DNA polymerase gene. (Feb 2017)
    Foscarnet 2.50 Low level resistance Laboratory strain Details Foscarnet resistance mutations mapping to atypical domains of the cytomegalovirus DNA polymerase gene. (Feb 2017)
    Foscarnet 3.10 Intermediate level resistance Laboratory strain Details Foscarnet resistance mutations mapping to atypical domains of the cytomegalovirus DNA polymerase gene. (Feb 2017)
    Ganciclovir 1.80 No resistance Laboratory strain Details Foscarnet resistance mutations mapping to atypical domains of the cytomegalovirus DNA polymerase gene. (Feb 2017)
    Ganciclovir 2.60 Low level resistance Laboratory strain Details Foscarnet resistance mutations mapping to atypical domains of the cytomegalovirus DNA polymerase gene. (Feb 2017)

    Mutations at the same locus:

    Mutant Resistances
    T552S Foscarnet: No resistance
    T552S Ganciclovir: Intermediate level resistance
    T552S Cidofovir: Low level resistance

    Tilloy et al., 2024
    Interdeposit Digital Number: IDDN.FR.001.420004.000.S.X.2024.000.31230