CHARMD

Comprehensive Herpesviruses Antiviral drug Resistance Mutation Database


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    E949K

    Antiviral assays:

    Antiviral EC50 ratio Phenotype Strain Source Marker Assay Reference
    Cidofovir 1.60 No resistance Clinical Isolate Details A new locus of foscarnet resistance in the cytomegalovirus UL54 DNA polymerase gene among uncharacterized mutations in recent clinical trials. (Feb 2026)
    Foscarnet 5.80 High level resistance Clinical Isolate Details A new locus of foscarnet resistance in the cytomegalovirus UL54 DNA polymerase gene among uncharacterized mutations in recent clinical trials. (Feb 2026)
    Ganciclovir 1.70 No resistance Clinical Isolate Details A new locus of foscarnet resistance in the cytomegalovirus UL54 DNA polymerase gene among uncharacterized mutations in recent clinical trials. (Feb 2026)

    Mutations at the same locus:

    Mutant Resistances
    E949Q Cidofovir: No resistance
    E949Q Foscarnet: Intermediate level resistance
    E949Q Ganciclovir: No resistance


    Tilloy et al., 2024
    Interdeposit Digital Number: IDDN.FR.001.420004.000.S.X.2024.000.31230