Herpesvirus Antiviral Resistance
Database


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    K513R

    Antiviral assays:

    Antiviral EC50 ratio Phenotype Strain Source Marker Assay Reference
    Ganciclovir 3.70 Intermediate level resistance Recombinant Details Improved detection of emerging drug-resistant mutant cytomegalovirus subpopulations by deep sequencing. (Aug 2014)
    Cidofovir 10.00 High level resistance Recombinant Details Improved detection of emerging drug-resistant mutant cytomegalovirus subpopulations by deep sequencing. (Aug 2014)
    Foscarnet 1.10 No resistance Recombinant Details Improved detection of emerging drug-resistant mutant cytomegalovirus subpopulations by deep sequencing. (Aug 2014)

    Mutations at the same locus:

    Mutant Resistances
    K513E Ganciclovir: High level resistance
    K513E Cidofovir: High level resistance
    K513E Foscarnet: No resistance
    K513N Ganciclovir: High level resistance
    K513N Cidofovir: High level resistance
    K513N Foscarnet: No resistance
    K513Q Ganciclovir: High level resistance
    K513Q Cidofovir: High level resistance
    K513Q Foscarnet: No resistance