Herpesvirus Antiviral Resistance
Database


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    Drug Resistance Assessed in a Phase 3 Clinical Trial of Maribavir Therapy for Refractory or Resistant Cytomegalovirus Infection in Transplant Recipients.

    Mutations:

    Mutant Gene Virus Antiviral EC50 ratio Phenotype
    N408H UL54 Human betaherpesvirus 5 Ganciclovir 2.00 Low level resistance
    N408H UL54 Human betaherpesvirus 5 Cidofovir 3.30 Intermediate level resistance
    N408H UL54 Human betaherpesvirus 5 Foscarnet 3.00 Intermediate level resistance
    L501F UL54 Human betaherpesvirus 5 Ganciclovir 2.60 Low level resistance
    L501F UL54 Human betaherpesvirus 5 Cidofovir 3.80 Intermediate level resistance
    L501F UL54 Human betaherpesvirus 5 Foscarnet 1.30 No resistance
    T503A UL54 Human betaherpesvirus 5 Ganciclovir 3.10 Intermediate level resistance
    T503A UL54 Human betaherpesvirus 5 Cidofovir 3.70 Intermediate level resistance
    T503A UL54 Human betaherpesvirus 5 Foscarnet 1.50 No resistance
    K513Q UL54 Human betaherpesvirus 5 Ganciclovir 6.60 High level resistance
    K513Q UL54 Human betaherpesvirus 5 Cidofovir 18.00 High level resistance
    K513Q UL54 Human betaherpesvirus 5 Foscarnet 1.00 No resistance
    P522T UL54 Human betaherpesvirus 5 Ganciclovir 2.10 Low level resistance
    P522T UL54 Human betaherpesvirus 5 Cidofovir 2.00 Low level resistance
    P522T UL54 Human betaherpesvirus 5 Foscarnet 1.40 No resistance
    L545F UL54 Human betaherpesvirus 5 Ganciclovir 4.00 Intermediate level resistance
    L545F UL54 Human betaherpesvirus 5 Cidofovir 11.00 High level resistance
    L545F UL54 Human betaherpesvirus 5 Foscarnet 1.20 No resistance
    C590F UL54 Human betaherpesvirus 5 Ganciclovir 1.60 No resistance
    C590F UL54 Human betaherpesvirus 5 Cidofovir 1.60 No resistance
    C590F UL54 Human betaherpesvirus 5 Foscarnet 2.30 Low level resistance
    981-982del UL54 Human betaherpesvirus 5 Ganciclovir 6.70 High level resistance
    981-982del UL54 Human betaherpesvirus 5 Cidofovir 4.20 Intermediate level resistance
    981-982del UL54 Human betaherpesvirus 5 Foscarnet 3.00 Intermediate level resistance
    E596Q UL97 Human betaherpesvirus 5 Ganciclovir 2.70 Low level resistance