CHARMD

Comprehensive Herpesviruses Antiviral drug Resistance Mutation Database


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    Drug Resistance Mutations and Associated Phenotypes Detected in Clinical Trials of Maribavir for Treatment of Cytomegalovirus Infection.

    Mutations:

    Mutant Gene Virus Antiviral EC50 ratio Phenotype
    G344D UL27 Human betaherpesvirus 5 Maribavir 0.90 No resistance
    P497S UL54 Human betaherpesvirus 5 Cidofovir 2.40 Low level resistance
    P497S UL54 Human betaherpesvirus 5 Foscarnet 0.80 No resistance
    P497S UL54 Human betaherpesvirus 5 Ganciclovir 1.90 No resistance
    L565V UL54 Human betaherpesvirus 5 Cidofovir 1.60 No resistance
    L565V UL54 Human betaherpesvirus 5 Foscarnet 3.70 Intermediate level resistance
    L565V UL54 Human betaherpesvirus 5 Ganciclovir 1.80 No resistance
    D594N UL54 Human betaherpesvirus 5 Cidofovir 1.00 No resistance
    D594N UL54 Human betaherpesvirus 5 Foscarnet 1.00 No resistance
    D594N UL54 Human betaherpesvirus 5 Ganciclovir 1.00 No resistance
    V823A UL54 Human betaherpesvirus 5 Cidofovir 3.60 Intermediate level resistance
    V823A UL54 Human betaherpesvirus 5 Foscarnet 0.50 No resistance
    V823A UL54 Human betaherpesvirus 5 Ganciclovir 2.40 Low level resistance
    A987V UL54 Human betaherpesvirus 5 Cidofovir 0.90 No resistance
    A987V UL54 Human betaherpesvirus 5 Foscarnet 3.10 Intermediate level resistance
    A987V UL54 Human betaherpesvirus 5 Ganciclovir 0.90 No resistance
    E989D UL54 Human betaherpesvirus 5 Cidofovir 1.90 No resistance
    E989D UL54 Human betaherpesvirus 5 Foscarnet 5.70 High level resistance
    E989D UL54 Human betaherpesvirus 5 Ganciclovir 3.20 Intermediate level resistance
    D981del2 UL54 Human betaherpesvirus 5 Cidofovir 3.70 Intermediate level resistance
    D981del2 UL54 Human betaherpesvirus 5 Foscarnet 3.10 Intermediate level resistance
    D981del2 UL54 Human betaherpesvirus 5 Ganciclovir 6.20 High level resistance
    T409M UL97 Human betaherpesvirus 5 Maribavir 78.00 High level resistance
    H411Y UL97 Human betaherpesvirus 5 Maribavir 15.00 High level resistance
    C480F UL97 Human betaherpesvirus 5 Ganciclovir 2.30 Low level resistance
    C480F UL97 Human betaherpesvirus 5 Maribavir 224.00 High level resistance
    C592G UL97 Human betaherpesvirus 5 Ganciclovir 3.10 Intermediate level resistance

    Tilloy et al., 2024
    Interdeposit Digital Number: IDDN.FR.001.420004.000.S.X.2024.000.31230