| Antiviral | EC50 ratio | Phenotype | Strain | Source | Marker | Assay | Reference |
|---|---|---|---|---|---|---|---|
| Ganciclovir | 4.90 | Intermediate level resistance | Recombinant | Details | Characterization of drug resistance-associated mutations in the human cytomegalovirus DNA polymerase gene by using recombinant mutant viruses generated from overlapping DNA fragments. (Jul 1998) | ||
| Cidofovir | 5.60 | High level resistance | Recombinant | Details | Characterization of drug resistance-associated mutations in the human cytomegalovirus DNA polymerase gene by using recombinant mutant viruses generated from overlapping DNA fragments. (Jul 1998) | ||
| Foscarnet | 1.30 | No resistance | Recombinant | Details | Characterization of drug resistance-associated mutations in the human cytomegalovirus DNA polymerase gene by using recombinant mutant viruses generated from overlapping DNA fragments. (Jul 1998) |
| Mutant | Resistances |
|---|---|
| N408H |
Ganciclovir:
|
| N408H |
Cidofovir:
|
| N408H |
Foscarnet:
|
| N408K |
Ganciclovir:
|
| N408K |
Cidofovir:
|
| N408K |
Foscarnet:
|
| N408K |
Brincidofovir:
|
| N408S |
Ganciclovir:
|
| N408S |
Cidofovir:
|
| N408S |
Foscarnet:
|