Herpesvirus Antiviral Resistance
Database


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    E756D

    Antiviral assays:

    Antiviral EC50 ratio Phenotype Strain Source Marker Assay Reference
    Ganciclovir 1.20 No resistance Recombinant Details Viral DNA polymerase mutations associated with drug resistance in human cytomegalovirus. (Jul 2003)
    Cidofovir 0.70 No resistance Recombinant Details Viral DNA polymerase mutations associated with drug resistance in human cytomegalovirus. (Jul 2003)
    Foscarnet 3.40 Intermediate level resistance Recombinant Details Viral DNA polymerase mutations associated with drug resistance in human cytomegalovirus. (Jul 2003)

    Mutations at the same locus:

    Mutant Resistances
    E756K Ganciclovir: Low level resistance
    E756K Cidofovir: Low level resistance
    E756K Foscarnet: At least High level resistance
    E756Q Ganciclovir: No resistance
    E756Q Cidofovir: No resistance
    E756Q Foscarnet: Intermediate level resistance