Codex_V5

E756D

Virus: Human betaherpesvirus 5
Gene: UL54
Resistance summary:*
- Ganciclovir: No resistance
- Cidofovir: No resistance
- Foscarnet: Intermediate level resistance

Antiviral	EC50 ratio	Phenotype	Marker	Assay	Reference
Ganciclovir	1.20	No resistance	Recombinant	Details	Viral DNA polymerase mutations associated with drug resistance in human cytomegalovirus. (Jul 2003)
Cidofovir	0.70	No resistance	Recombinant	Details	Viral DNA polymerase mutations associated with drug resistance in human cytomegalovirus. (Jul 2003)
Foscarnet	3.40	Intermediate level resistance	Recombinant	Details	Viral DNA polymerase mutations associated with drug resistance in human cytomegalovirus. (Jul 2003)

Mutant	Resistances
E756K	Ganciclovir: Low level resistance
E756K	Cidofovir: Low level resistance
E756K	Foscarnet: At least High level resistance
E756Q	Ganciclovir: No resistance
E756Q	Cidofovir: No resistance
E756Q	Foscarnet: Intermediate level resistance