CHARMD

Comprehensive Herpesviruses Antiviral drug Resistance Mutation Database


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    P522A

    Antiviral assays:

    Antiviral EC50 ratio Phenotype Strain Source Marker Assay Reference
    Ganciclovir 3.00 Intermediate level resistance Recombinant Details Contrasting drug resistance phenotypes resulting from cytomegalovirus DNA polymerase mutations at the same exonuclease locus. (Sep 2008)
    Cidofovir 4.10 Intermediate level resistance Recombinant Details Contrasting drug resistance phenotypes resulting from cytomegalovirus DNA polymerase mutations at the same exonuclease locus. (Sep 2008)
    Foscarnet 1.00 No resistance Recombinant Details Contrasting drug resistance phenotypes resulting from cytomegalovirus DNA polymerase mutations at the same exonuclease locus. (Sep 2008)

    Mutations at the same locus:

    Mutant Resistances
    P522L Natural polymorphism
    P522S Ganciclovir: Intermediate level resistance
    P522S Cidofovir: Intermediate level resistance
    P522S Foscarnet: No resistance
    P522T Ganciclovir: Low level resistance
    P522T Cidofovir: Low level resistance
    P522T Foscarnet: No resistance


    Tilloy et al., 2024
    Interdeposit Digital Number: IDDN.FR.001.420004.000.S.X.2024.000.31230