Herpesvirus Antiviral Resistance
Database


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    D413A

    Antiviral assays:

    Antiviral EC50 ratio Phenotype Strain Source Marker Assay Reference
    Ganciclovir 6.50 High level resistance Recombinant Details Development of new cytomegalovirus UL97 and DNA polymerase mutations conferring drug resistance after valganciclovir therapy in allogeneic stem cell recipients. (Feb 2007)
    Cidofovir 11.00 High level resistance Recombinant Details Development of new cytomegalovirus UL97 and DNA polymerase mutations conferring drug resistance after valganciclovir therapy in allogeneic stem cell recipients. (Feb 2007)
    Foscarnet 0.80 No resistance Recombinant Details Development of new cytomegalovirus UL97 and DNA polymerase mutations conferring drug resistance after valganciclovir therapy in allogeneic stem cell recipients. (Feb 2007)

    Mutations at the same locus:

    Mutant Resistances
    D413del Brincidofovir: High level resistance
    D413del Cidofovir: High level resistance
    D413del Ganciclovir: Intermediate level resistance
    D413del Foscarnet: No resistance
    D413E Ganciclovir: Intermediate level resistance
    D413E Cidofovir: Intermediate level resistance
    D413E Foscarnet: No resistance
    D413N Ganciclovir: Intermediate level resistance
    D413N Cidofovir: High level resistance
    D413N Foscarnet: No resistance
    D413Y Brincidofovir: High level resistance
    D413Y Cidofovir: High level resistance
    D413Y Ganciclovir: Intermediate level resistance
    D413Y Foscarnet: No resistance