Codex_V5

T552S

Virus: Human betaherpesvirus 5
Gene: UL54
Resistance summary:*
- Foscarnet: No resistance
- Ganciclovir: Intermediate level resistance
- Cidofovir: Low level resistance

Antiviral	EC50 ratio	Phenotype	Source	Marker	Assay	Reference
Foscarnet	0.50	No resistance	Laboratory strain, Clinical Isolate	Recombinant	Details	Immune restoration therapy for multidrug-resistant CMV disease in an allogenic stem cell transplant recipient. (May 2022)
Ganciclovir	3.00	Intermediate level resistance	Laboratory strain, Clinical Isolate	Recombinant	Details	Immune restoration therapy for multidrug-resistant CMV disease in an allogenic stem cell transplant recipient. (May 2022)
Cidofovir	2.70	Low level resistance	Laboratory strain, Clinical Isolate	Recombinant	Details	Immune restoration therapy for multidrug-resistant CMV disease in an allogenic stem cell transplant recipient. (May 2022)

Mutant	Resistances
T552N	Ganciclovir: No resistance
T552N	Cidofovir: No resistance
T552N	Foscarnet: Low level resistance
T552N	Cidofovir: No resistance
T552N	Cidofovir: No resistance
T552N	Foscarnet: Low level resistance
T552N	Foscarnet: Intermediate level resistance
T552N	Ganciclovir: No resistance
T552N	Ganciclovir: Low level resistance