Herpesvirus Antiviral Resistance
Database


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    F412L

    Antiviral assays:

    Antiviral EC50 ratio Phenotype Strain Source Marker Assay Reference
    Ganciclovir 4.60 Intermediate level resistance Recombinant Details Phenotypic diversity of cytomegalovirus DNA polymerase gene variants observed after antiviral therapy. (Apr 2011)
    Cidofovir 9.40 High level resistance Recombinant Details Phenotypic diversity of cytomegalovirus DNA polymerase gene variants observed after antiviral therapy. (Apr 2011)
    Foscarnet 1.10 No resistance Recombinant Details Phenotypic diversity of cytomegalovirus DNA polymerase gene variants observed after antiviral therapy. (Apr 2011)

    Mutations at the same locus:

    Mutant Resistances
    F412C Ganciclovir: Intermediate level resistance
    F412C Cidofovir: High level resistance
    F412C Foscarnet: No resistance
    F412S Ganciclovir: High level resistance
    F412S Cidofovir: High level resistance
    F412S Foscarnet: No resistance
    F412V Ganciclovir: Intermediate level resistance
    F412V Cidofovir: High level resistance
    F412V Foscarnet: No resistance