CHARMD

Comprehensive Herpesviruses Antiviral drug Resistance Mutation Database


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    Genotypic and Phenotypic Study of Antiviral Resistance Mutations in Refractory Cytomegalovirus Infection.

    Mutations:

    Mutant Gene Virus Antiviral EC50 ratio Phenotype
    G441S UL54 Human betaherpesvirus 5 Natural polymorphism
    F460S UL54 Human betaherpesvirus 5 Natural polymorphism
    R512C UL54 Human betaherpesvirus 5 Natural polymorphism
    A543V UL54 Human betaherpesvirus 5 Cidofovir 10.00 High level resistance
    A928T UL54 Human betaherpesvirus 5 Ganciclovir >3.00 At least Intermediate level resistance
    A928T UL54 Human betaherpesvirus 5 Cidofovir >3.00 At least Intermediate level resistance
    A928T UL54 Human betaherpesvirus 5 Foscarnet >3.00 At least Intermediate level resistance
    F345L UL56 Human betaherpesvirus 5 Letermovir 0.95-1.03 Range of values of No resistance


    Tilloy et al., 2024
    Interdeposit Digital Number: IDDN.FR.001.420004.000.S.X.2024.000.31230