CHARMD

Comprehensive Herpesviruses Antiviral drug Resistance Mutation Database


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    L516W

    Antiviral assays:

    Antiviral EC50 ratio Phenotype Strain Source Marker Assay Reference
    Ganciclovir 4.20 Intermediate level resistance Details Identification of resistance-associated HCMV UL97- and UL54-mutations and a UL97-polymporphism with impact on phenotypic drug-resistance. (Jul 2016)
    Cidofovir 8.49 High level resistance Details Identification of resistance-associated HCMV UL97- and UL54-mutations and a UL97-polymporphism with impact on phenotypic drug-resistance. (Jul 2016)
    Foscarnet 1.22 No resistance Details Identification of resistance-associated HCMV UL97- and UL54-mutations and a UL97-polymporphism with impact on phenotypic drug-resistance. (Jul 2016)

    Mutations at the same locus:

    Mutant Resistances
    L516R Ganciclovir: Low level resistance
    L516R Cidofovir: High level resistance
    L516R Foscarnet: No resistance


    Tilloy et al., 2024
    Interdeposit Digital Number: IDDN.FR.001.420004.000.S.X.2024.000.31230