CHARMD

Comprehensive Herpesviruses Antiviral drug Resistance Mutation Database


  • TOP

    P522T

    Antiviral assays:

    Antiviral EC50 ratio Phenotype Strain Source Marker Assay Reference
    Ganciclovir 2.10 Low level resistance Recombinant Details Drug Resistance Assessed in a Phase 3 Clinical Trial of Maribavir Therapy for Refractory or Resistant Cytomegalovirus Infection in Transplant Recipients. (Feb 2024)
    Cidofovir 2.00 Low level resistance Recombinant Details Drug Resistance Assessed in a Phase 3 Clinical Trial of Maribavir Therapy for Refractory or Resistant Cytomegalovirus Infection in Transplant Recipients. (Feb 2024)
    Foscarnet 1.40 No resistance Recombinant Details Drug Resistance Assessed in a Phase 3 Clinical Trial of Maribavir Therapy for Refractory or Resistant Cytomegalovirus Infection in Transplant Recipients. (Feb 2024)

    Mutations at the same locus:

    Mutant Resistances
    P522A Ganciclovir: Intermediate level resistance
    P522A Cidofovir: Intermediate level resistance
    P522A Foscarnet: No resistance
    P522L Natural polymorphism
    P522S Ganciclovir: Intermediate level resistance
    P522S Cidofovir: Intermediate level resistance
    P522S Foscarnet: No resistance


    Tilloy et al., 2024
    Interdeposit Digital Number: IDDN.FR.001.420004.000.S.X.2024.000.31230