Codex_V5

D542E

Antiviral	EC50 ratio	Phenotype	Source	Marker	Assay	Reference
Ganciclovir	1.50	No resistance		Recombinant	Details	Selection and recombinant phenotyping of a novel CMX001 and cidofovir resistance mutation in human cytomegalovirus. (Jul 2013)
Cidofovir	12.00	High level resistance		Recombinant	Details	Selection and recombinant phenotyping of a novel CMX001 and cidofovir resistance mutation in human cytomegalovirus. (Jul 2013)
Foscarnet	1.70	No resistance		Recombinant	Details	Selection and recombinant phenotyping of a novel CMX001 and cidofovir resistance mutation in human cytomegalovirus. (Jul 2013)
Cidofovir	13.00	High level resistance	Laboratory strain, Clinical Isolate		Details	A new locus of foscarnet resistance in the cytomegalovirus UL54 DNA polymerase gene among uncharacterized mutations in recent clinical trials. (Feb 2026)
Foscarnet	0.50	No resistance	Laboratory strain, Clinical Isolate		Details	A new locus of foscarnet resistance in the cytomegalovirus UL54 DNA polymerase gene among uncharacterized mutations in recent clinical trials. (Feb 2026)
Ganciclovir	3.50	Intermediate level resistance	Laboratory strain, Clinical Isolate		Details	A new locus of foscarnet resistance in the cytomegalovirus UL54 DNA polymerase gene among uncharacterized mutations in recent clinical trials. (Feb 2026)