Codex_V5

A987G

Virus: Human betaherpesvirus 5
Gene: UL54
Resistance summary:*
- Ganciclovir: High level resistance
- Cidofovir: High level resistance
- Foscarnet: No resistance
- Cidofovir: High level resistance
- Cidofovir: High level resistance

Antiviral	EC50 ratio	Phenotype	Source	Marker	Assay	Reference
Ganciclovir	5.30	High level resistance		Recombinant	Details	Characterization of drug resistance-associated mutations in the human cytomegalovirus DNA polymerase gene by using recombinant mutant viruses generated from overlapping DNA fragments. (Jul 1998)
Cidofovir	11.30	High level resistance		Recombinant	Details	Characterization of drug resistance-associated mutations in the human cytomegalovirus DNA polymerase gene by using recombinant mutant viruses generated from overlapping DNA fragments. (Jul 1998)
Foscarnet	1.20	No resistance		Recombinant	Details	Characterization of drug resistance-associated mutations in the human cytomegalovirus DNA polymerase gene by using recombinant mutant viruses generated from overlapping DNA fragments. (Jul 1998)
Cidofovir	8.50	High level resistance	Laboratory strain, Clinical Isolate		Details	Foscarnet resistance mutations mapping to atypical domains of the cytomegalovirus DNA polymerase gene. (Feb 2017)
Cidofovir	5.00	High level resistance	Laboratory strain, Clinical Isolate		Details	Foscarnet resistance mutations mapping to atypical domains of the cytomegalovirus DNA polymerase gene. (Feb 2017)

Mutant	Resistances
A987V	Cidofovir: No resistance
A987V	Foscarnet: Intermediate level resistance
A987V	Ganciclovir: No resistance