CHARMD

TOP

• Mutant: K805Q
• Gene: UL54
• Virus: Human betaherpesvirus 5
• Strain:
• Reference: Characterization of drug resistance-associated mutations in the human cytomegalovirus DNA polymerase gene by using recombinant mutant viruses generated from overlapping DNA fragments. (Jul 1998)


• Antiviral: Cidofovir
• EC50 ratio: 2.20
• Phenotype: Low level resistance
• Passage: N/A
• Source: N/A
• Marker: Recombinant


• Details:
  • PRA, ELISA tests, flow cytometry and DNA-DNA hybridization assays, quantitative real-time PCR, reporter cell lines, polymerase biochemical assays, marker transfer


• Observations:
  • Autre publi ID : 9207351 20587852