CHARMD

Comprehensive Herpesviruses Antiviral drug Resistance Mutation Database


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    L545F

    Antiviral assays:

    Antiviral EC50 ratio Phenotype Strain Source Marker Assay Reference
    Ganciclovir 4.00 Intermediate level resistance Recombinant Details Drug Resistance Assessed in a Phase 3 Clinical Trial of Maribavir Therapy for Refractory or Resistant Cytomegalovirus Infection in Transplant Recipients. (Feb 2024)
    Cidofovir 11.00 High level resistance Recombinant Details Drug Resistance Assessed in a Phase 3 Clinical Trial of Maribavir Therapy for Refractory or Resistant Cytomegalovirus Infection in Transplant Recipients. (Feb 2024)
    Foscarnet 1.20 No resistance Recombinant Details Drug Resistance Assessed in a Phase 3 Clinical Trial of Maribavir Therapy for Refractory or Resistant Cytomegalovirus Infection in Transplant Recipients. (Feb 2024)

    Mutations at the same locus:

    Mutant Resistances
    L545S Ganciclovir: Intermediate level resistance
    L545S Cidofovir: High level resistance
    L545S Foscarnet: No resistance
    L545W Ganciclovir: Intermediate level resistance
    L545W Cidofovir: High level resistance
    L545W Foscarnet: No resistance


    Tilloy et al., 2024
    Interdeposit Digital Number: IDDN.FR.001.420004.000.S.X.2024.000.31230