CHARMD

Comprehensive Herpesviruses Antiviral drug Resistance Mutation Database


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    A543V

    Antiviral assays:

    Antiviral EC50 ratio Phenotype Strain Source Marker Assay Reference
    Cidofovir 10.00 High level resistance Details Genotypic and Phenotypic Study of Antiviral Resistance Mutations in Refractory Cytomegalovirus Infection. (Nov 2022)
    Cidofovir 3.20 Intermediate level resistance Laboratory strain, Clinical Isolate Details A new locus of foscarnet resistance in the cytomegalovirus UL54 DNA polymerase gene among uncharacterized mutations in recent clinical trials. (Feb 2026)
    Foscarnet 0.70 No resistance Laboratory strain, Clinical Isolate Details A new locus of foscarnet resistance in the cytomegalovirus UL54 DNA polymerase gene among uncharacterized mutations in recent clinical trials. (Feb 2026)
    Ganciclovir 2.10 Low level resistance Laboratory strain, Clinical Isolate Details A new locus of foscarnet resistance in the cytomegalovirus UL54 DNA polymerase gene among uncharacterized mutations in recent clinical trials. (Feb 2026)

    Mutations at the same locus:

    Mutant Resistances
    A543S Ganciclovir: No resistance
    A543S Cidofovir: No resistance
    A543S Foscarnet: No resistance


    Tilloy et al., 2024
    Interdeposit Digital Number: IDDN.FR.001.420004.000.S.X.2024.000.31230