CHARMD

Comprehensive Herpesviruses Antiviral drug Resistance Mutation Database

Immune restoration therapy for multidrug-resistant CMV disease in an allogenic stem cell transplant recipient.

Pubmed_id: 35021130
Journal: Current research in translational medicine
Genbank_id: No known Genbank_id
Date: May 2022
Volume: 70
Issue: 2
Pages: 103329
Author(s): Paccoud O, Alain S, Gozlan J, Jarboui S, Boutolleau D, Hantz S, Battipaglia G, Paviglianiti A, Duléry R, Malard F, Médiavilla C, Sestili S, Gaugler B, Meynard JL, Pacanowski J, Mohty M, Brissot E,

Abstract:

Mutations:

Mutant	Gene	Virus	Antiviral	EC50 ratio	Phenotype
T552S	UL54	Human betaherpesvirus 5	Foscarnet	0.50	No resistance
T552S	UL54	Human betaherpesvirus 5	Ganciclovir	3.00	Intermediate level resistance
T552S	UL54	Human betaherpesvirus 5	Cidofovir	2.70	Low level resistance

Tilloy et al., 2024

Interdeposit Digital Number: IDDN.FR.001.420004.000.S.X.2024.000.31230