Herpesvirus Antiviral Resistance
Database


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    L545W

    Antiviral assays:

    Antiviral EC50 ratio Phenotype Strain Source Marker Assay Reference
    Ganciclovir 4.90 Intermediate level resistance Recombinant Details Phenotypic diversity of cytomegalovirus DNA polymerase gene variants observed after antiviral therapy. (Apr 2011)
    Cidofovir 6.30 High level resistance Recombinant Details Phenotypic diversity of cytomegalovirus DNA polymerase gene variants observed after antiviral therapy. (Apr 2011)
    Foscarnet 1.30 No resistance Recombinant Details Phenotypic diversity of cytomegalovirus DNA polymerase gene variants observed after antiviral therapy. (Apr 2011)

    Mutations at the same locus:

    Mutant Resistances
    L545F Ganciclovir: Intermediate level resistance
    L545F Cidofovir: High level resistance
    L545F Foscarnet: No resistance
    L545S Ganciclovir: Intermediate level resistance
    L545S Cidofovir: High level resistance
    L545S Foscarnet: No resistance