Codex_V5

V715M

Virus: Human betaherpesvirus 5
Gene: UL54
Resistance summary:*
- Ganciclovir: No resistance
- Cidofovir: No resistance
- Foscarnet: High level resistance

Antiviral	EC50 ratio	Phenotype	Marker	Assay	Reference
Ganciclovir	1.00	No resistance	Recombinant	Details	Single amino acid changes in the DNA polymerase confer foscarnet resistance and slow-growth phenotype, while mutations in the UL97-encoded phosphotransferase confer ganciclovir resistance in three double-resistant human cytomegalovirus strains recovered from patients with AIDS. (Mar 1996)
Cidofovir	1.10	No resistance	Recombinant	Details	Single amino acid changes in the DNA polymerase confer foscarnet resistance and slow-growth phenotype, while mutations in the UL97-encoded phosphotransferase confer ganciclovir resistance in three double-resistant human cytomegalovirus strains recovered from patients with AIDS. (Mar 1996)
Foscarnet	5.50	High level resistance	Recombinant	Details	Single amino acid changes in the DNA polymerase confer foscarnet resistance and slow-growth phenotype, while mutations in the UL97-encoded phosphotransferase confer ganciclovir resistance in three double-resistant human cytomegalovirus strains recovered from patients with AIDS. (Mar 1996)

Mutant	Resistances
V715A	Ganciclovir: No resistance
V715A	Cidofovir: Possible hypersensitivity, no resistance
V715A	Foscarnet: Low level resistance