CHARMD

Comprehensive Herpesviruses Antiviral drug Resistance Mutation Database


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    N495K

    Antiviral assays:

    Antiviral EC50 ratio Phenotype Strain Source Marker Assay Reference
    Ganciclovir 1.10 No resistance Recombinant Details A novel mutation in the UL54 gene of human cytomegalovirus isolates that confers resistance to foscarnet. ( 2006)
    Cidofovir 1.10 No resistance Recombinant Details A novel mutation in the UL54 gene of human cytomegalovirus isolates that confers resistance to foscarnet. ( 2006)
    Foscarnet 3.40 Intermediate level resistance Recombinant Details A novel mutation in the UL54 gene of human cytomegalovirus isolates that confers resistance to foscarnet. ( 2006)
    Cidofovir 1.20 No resistance Laboratory strain, Clinical Isolate Details Foscarnet resistance mutations mapping to atypical domains of the cytomegalovirus DNA polymerase gene. (Feb 2017)
    Cidofovir 1.00 No resistance Laboratory strain, Clinical Isolate Details Foscarnet resistance mutations mapping to atypical domains of the cytomegalovirus DNA polymerase gene. (Feb 2017)
    Foscarnet 2.50 Low level resistance Laboratory strain, Clinical Isolate Details Foscarnet resistance mutations mapping to atypical domains of the cytomegalovirus DNA polymerase gene. (Feb 2017)
    Foscarnet 2.60 Low level resistance Laboratory strain, Clinical Isolate Details Foscarnet resistance mutations mapping to atypical domains of the cytomegalovirus DNA polymerase gene. (Feb 2017)
    Ganciclovir 1.30 No resistance Laboratory strain, Clinical Isolate Details Foscarnet resistance mutations mapping to atypical domains of the cytomegalovirus DNA polymerase gene. (Feb 2017)
    Ganciclovir 1.40 No resistance Laboratory strain, Clinical Isolate Details Foscarnet resistance mutations mapping to atypical domains of the cytomegalovirus DNA polymerase gene. (Feb 2017)

    Tilloy et al., 2024
    Interdeposit Digital Number: IDDN.FR.001.420004.000.S.X.2024.000.31230