| Antiviral | EC50 ratio | Phenotype | Strain | Source | Marker | Assay | Reference |
|---|---|---|---|---|---|---|---|
| Ganciclovir | 6.00 | High level resistance | Recombinant | Details | A point mutation in the human cytomegalovirus DNA polymerase gene selected in vitro by cidofovir confers a slow replication phenotype in cell culture. (Sep 1998) | ||
| Cidofovir | 12.50 | High level resistance | Recombinant | Details | A point mutation in the human cytomegalovirus DNA polymerase gene selected in vitro by cidofovir confers a slow replication phenotype in cell culture. (Sep 1998) | ||
| Foscarnet | 1.50 | No resistance | Recombinant | Details | A point mutation in the human cytomegalovirus DNA polymerase gene selected in vitro by cidofovir confers a slow replication phenotype in cell culture. (Sep 1998) |
| Mutant | Resistances |
|---|---|
| K513E |
Ganciclovir:
|
| K513E |
Cidofovir:
|
| K513E |
Foscarnet:
|
| K513Q |
Ganciclovir:
|
| K513Q |
Cidofovir:
|
| K513Q |
Foscarnet:
|
| K513R |
Ganciclovir:
|
| K513R |
Cidofovir:
|
| K513R |
Foscarnet:
|