CHARMD

Comprehensive Herpesviruses Antiviral drug Resistance Mutation Database


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    Q578L

    Antiviral assays:

    Antiviral EC50 ratio Phenotype Strain Source Marker Assay Reference
    Ganciclovir 1.90 No resistance Recombinant Details Improved detection of emerging drug-resistant mutant cytomegalovirus subpopulations by deep sequencing. (Aug 2014)
    Cidofovir 0.80 No resistance Recombinant Details Improved detection of emerging drug-resistant mutant cytomegalovirus subpopulations by deep sequencing. (Aug 2014)
    Foscarnet 3.00 Intermediate level resistance Recombinant Details Improved detection of emerging drug-resistant mutant cytomegalovirus subpopulations by deep sequencing. (Aug 2014)

    Mutations at the same locus:

    Mutant Resistances
    Q578H Ganciclovir: Intermediate level resistance
    Q578H Cidofovir: Low level resistance
    Q578H Foscarnet: Intermediate level resistance


    Tilloy et al., 2024
    Interdeposit Digital Number: IDDN.FR.001.420004.000.S.X.2024.000.31230