Codex_V5

N408S

Virus: Human betaherpesvirus 5
Gene: UL54
Resistance summary:*
- Ganciclovir: Intermediate level resistance
- Cidofovir: High level resistance
- Foscarnet: No resistance

Antiviral	EC50 ratio	Phenotype	Marker	Assay	Reference
Ganciclovir	3.10	Intermediate level resistance	Recombinant	Details	Novel DNA polymerase mutations conferring cytomegalovirus resistance: input of BAC-recombinant phenotyping and 3D model. (Apr 2013)
Cidofovir	7.50	High level resistance	Recombinant	Details	Novel DNA polymerase mutations conferring cytomegalovirus resistance: input of BAC-recombinant phenotyping and 3D model. (Apr 2013)
Foscarnet	1.00	No resistance	Recombinant	Details	Novel DNA polymerase mutations conferring cytomegalovirus resistance: input of BAC-recombinant phenotyping and 3D model. (Apr 2013)

Mutant	Resistances
N408D	Ganciclovir: Intermediate level resistance
N408D	Cidofovir: High level resistance
N408D	Foscarnet: No resistance
N408H	Ganciclovir: Low level resistance
N408H	Cidofovir: Intermediate level resistance
N408H	Foscarnet: Intermediate level resistance
N408K	Ganciclovir: Intermediate level resistance
N408K	Cidofovir: High level resistance
N408K	Foscarnet: No resistance
N408K	Brincidofovir: High level resistance