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Artesunate as a potent antiviral agent in a patient with late drug-resistant cytomegalovirus infection after hematopoietic stem cell transplantation.
- Pubmed_id: 18419454
- Journal: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
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Genbank_id: No known Genbank_id
- Date: May 2008
- Volume: 46
- Issue: 9
- Pages: 1455-7
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Author(s):
Shapira MY,
Resnick IB,
Chou S,
Neumann AU,
Lurain NS,
Stamminger T,
Caplan O,
Saleh N,
Efferth T,
Marschall M,
Wolf DG,
- Abstract: This is the first report of treatment of cytomegalovirus infection with artesunate, for a stem cell transplant recipient with a newly identified foscarnet-resistant and ganciclovir-resistant DNA polymerase L776M mutation. Artesunate treatment resulted in a 1.7-2.1-log reduction in viral load by treatment day 7, with a viral half-life of 0.9-1.9 days, indicating a highly effective block in viral replication.
