CHARMD

Comprehensive Herpesviruses Antiviral drug Resistance Mutation Database


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    D588E

    Antiviral assays:

    Antiviral EC50 ratio Phenotype Strain Source Marker Assay Reference
    Ganciclovir 1.30 No resistance Recombinant Details Characterization of drug resistance-associated mutations in the human cytomegalovirus DNA polymerase gene by using recombinant mutant viruses generated from overlapping DNA fragments. (Jul 1998)
    Cidofovir 1.10 No resistance Recombinant Details Characterization of drug resistance-associated mutations in the human cytomegalovirus DNA polymerase gene by using recombinant mutant viruses generated from overlapping DNA fragments. (Jul 1998)
    Foscarnet 2.30 Low level resistance Recombinant Details Characterization of drug resistance-associated mutations in the human cytomegalovirus DNA polymerase gene by using recombinant mutant viruses generated from overlapping DNA fragments. (Jul 1998)

    Mutations at the same locus:

    Mutant Resistances
    D588N Ganciclovir: Intermediate level resistance
    D588N Cidofovir: Low level resistance
    D588N Foscarnet: Range of values between Intermediate level resistance and High level resistance


    Tilloy et al., 2024
    Interdeposit Digital Number: IDDN.FR.001.420004.000.S.X.2024.000.31230