CHARMD
Comprehensive Herpesviruses Antiviral drug Resistance Mutation Database
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Last update : Mon 20 Apr 2026
TOP
K426E
Virus:
Human betaherpesvirus 5
Gene:
UL54
Resistance summary:*
Cidofovir:
No resistance
Cidofovir:
No resistance
Foscarnet:
No resistance
Foscarnet:
No resistance
Ganciclovir:
No resistance
Ganciclovir:
No resistance
*If there is more than one line per antiviral, please refer to the table below
Antiviral assays:
Antiviral
EC50 ratio
Phenotype
Strain
Source
Marker
Assay
Reference
Cidofovir
1.00
No resistance
Laboratory strain
Details
Foscarnet resistance mutations mapping to atypical domains of the cytomegalovirus DNA polymerase gene. (Feb 2017)
Cidofovir
0.90
No resistance
Laboratory strain
Details
Foscarnet resistance mutations mapping to atypical domains of the cytomegalovirus DNA polymerase gene. (Feb 2017)
Foscarnet
1.10
No resistance
Laboratory strain
Details
Foscarnet resistance mutations mapping to atypical domains of the cytomegalovirus DNA polymerase gene. (Feb 2017)
Foscarnet
0.90
No resistance
Laboratory strain
Details
Foscarnet resistance mutations mapping to atypical domains of the cytomegalovirus DNA polymerase gene. (Feb 2017)
Ganciclovir
1.00
No resistance
Laboratory strain
Details
Foscarnet resistance mutations mapping to atypical domains of the cytomegalovirus DNA polymerase gene. (Feb 2017)
Ganciclovir
1.10
No resistance
Laboratory strain
Details
Foscarnet resistance mutations mapping to atypical domains of the cytomegalovirus DNA polymerase gene. (Feb 2017)
Mutations at the same locus:
Mutant
Resistances
K426R
Natural polymorphism
Tilloy
et al.
, 2024
Interdeposit Digital Number: IDDN.FR.001.420004.000.S.X.2024.000.31230
