CHARMD

Comprehensive Herpesviruses Antiviral drug Resistance Mutation Database


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    D588N

    Antiviral assays:

    Antiviral EC50 ratio Phenotype Strain Source Marker Assay Reference
    Ganciclovir 3.80 Intermediate level resistance N/A N/A Recombinant Details How evolution of mutations conferring drug resistance affects viral dynamics and clinical outcomes of cytomegalovirus-infected hematopoietic cell transplant recipients. (Jan 2005)
    Cidofovir 2.70 Low level resistance N/A N/A Recombinant Details How evolution of mutations conferring drug resistance affects viral dynamics and clinical outcomes of cytomegalovirus-infected hematopoietic cell transplant recipients. (Jan 2005)
    Foscarnet 3.20-9.00 Range of values between Intermediate level resistance and High level resistance N/A N/A Recombinant Details How evolution of mutations conferring drug resistance affects viral dynamics and clinical outcomes of cytomegalovirus-infected hematopoietic cell transplant recipients. (Jan 2005)

    Mutations at the same locus:

    Mutant Resistances
    D588E Ganciclovir: No resistance
    Cidofovir: No resistance
    Foscarnet: Low level resistance


    Tilloy et al., 2024
    Interdeposit Digital Number: IDDN.FR.001.420004.000.S.X.2024.000.31230