Herpesvirus Antiviral Resistance
Database


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    D588N

    Antiviral assays:

    Antiviral EC50 ratio Phenotype Strain Source Marker Assay Reference
    Ganciclovir 3.80 Intermediate level resistance Recombinant Details How evolution of mutations conferring drug resistance affects viral dynamics and clinical outcomes of cytomegalovirus-infected hematopoietic cell transplant recipients. (Jan 2005)
    Cidofovir 2.70 Low level resistance Recombinant Details How evolution of mutations conferring drug resistance affects viral dynamics and clinical outcomes of cytomegalovirus-infected hematopoietic cell transplant recipients. (Jan 2005)
    Foscarnet 3.20-9.00 Range of values between Intermediate level resistance and High level resistance Recombinant Details How evolution of mutations conferring drug resistance affects viral dynamics and clinical outcomes of cytomegalovirus-infected hematopoietic cell transplant recipients. (Jan 2005)

    Mutations at the same locus:

    Mutant Resistances
    D588E Ganciclovir: No resistance
    D588E Cidofovir: No resistance
    D588E Foscarnet: Low level resistance