Codex_V5

D515Y

Virus: Human betaherpesvirus 5
Gene: UL54
Resistance summary:*
- Ganciclovir: High level resistance
- Cidofovir: No resistance
- Foscarnet: Intermediate level resistance

Antiviral	EC50 ratio	Phenotype	Marker	Assay	Reference
Ganciclovir	6.20	High level resistance	Recombinant	Details	Contrasting effect of new HCMV pUL54 mutations on antiviral drug susceptibility: Benefits and limits of 3D analysis. (May 2016)
Cidofovir	0.87	No resistance	Recombinant	Details	Contrasting effect of new HCMV pUL54 mutations on antiviral drug susceptibility: Benefits and limits of 3D analysis. (May 2016)
Foscarnet	4.70	Intermediate level resistance	Recombinant	Details	Contrasting effect of new HCMV pUL54 mutations on antiviral drug susceptibility: Benefits and limits of 3D analysis. (May 2016)

Mutant	Resistances
D515E	Ganciclovir: Low level resistance
D515E	Cidofovir: No resistance
D515E	Foscarnet: Intermediate level resistance
D515G	Natural polymorphism