Codex_V5

D515Y

Antiviral	EC50 ratio	Phenotype	Source	Marker	Assay	Reference
Ganciclovir	6.20	High level resistance		Recombinant	Details	Contrasting effect of new HCMV pUL54 mutations on antiviral drug susceptibility: Benefits and limits of 3D analysis. (May 2016)
Cidofovir	0.87	No resistance		Recombinant	Details	Contrasting effect of new HCMV pUL54 mutations on antiviral drug susceptibility: Benefits and limits of 3D analysis. (May 2016)
Foscarnet	4.70	Intermediate level resistance		Recombinant	Details	Contrasting effect of new HCMV pUL54 mutations on antiviral drug susceptibility: Benefits and limits of 3D analysis. (May 2016)
Cidofovir	2.60	Low level resistance	Laboratory strain, Clinical Isolate		Details	Emergence of letermovir resistance in a lung transplant recipient with ganciclovir-resistant cytomegalovirus infection. (Dec 2018)
Foscarnet	1.10	No resistance	Laboratory strain, Clinical Isolate		Details	Emergence of letermovir resistance in a lung transplant recipient with ganciclovir-resistant cytomegalovirus infection. (Dec 2018)
Ganciclovir	3.20	Intermediate level resistance	Laboratory strain, Clinical Isolate		Details	Emergence of letermovir resistance in a lung transplant recipient with ganciclovir-resistant cytomegalovirus infection. (Dec 2018)

Mutant	Resistances
D515E	Ganciclovir: Low level resistance
D515E	Cidofovir: No resistance
D515E	Foscarnet: Intermediate level resistance
D515E	Cidofovir: No resistance
D515E	Foscarnet: No resistance
D515E	Ganciclovir: No resistance
D515G	Natural polymorphism