CHARMD

Comprehensive Herpesviruses Antiviral drug Resistance Mutation Database


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    A594P

    Antiviral assays:

    Antiviral EC50 ratio Phenotype Strain Source Marker Assay Reference
    Ganciclovir 7.90 High level resistance Laboratory strain, Clinical Isolate Recombinant Details Ganciclovir and maribavir cross-resistance revisited: Relative drug susceptibilities of canonical cytomegalovirus mutants. (Feb 2024)
    Maribavir 1.60 No resistance Laboratory strain, Clinical Isolate Recombinant Details Ganciclovir and maribavir cross-resistance revisited: Relative drug susceptibilities of canonical cytomegalovirus mutants. (Feb 2024)

    Mutations at the same locus:

    Mutant Resistances
    A594E Ganciclovir: Intermediate level resistance
    A594G Ganciclovir: High level resistance
    A594S Ganciclovir: Range of values between Low level resistance and Intermediate level resistance
    A594T Ganciclovir: High level resistance
    A594T Maribavir: No resistance
    A594V Filociclovir: Range of values between Low level resistance and Intermediate level resistance
    A594V Maribavir: No resistance
    A594V Ganciclovir: High level resistance

    Tilloy et al., 2024
    Interdeposit Digital Number: IDDN.FR.001.420004.000.S.X.2024.000.31230