Codex_V5

A594S

Virus: Human betaherpesvirus 5
Gene: UL97
Resistance summary:*
- Ganciclovir: Range of values between Low level resistance and Intermediate level resistance

Antiviral	EC50 ratio	Phenotype	Strain	Source	Marker	Assay	Reference
Ganciclovir	2.20-4.90	Range of values between Low level resistance and Intermediate level resistance		Laboratory strain, Clinical Isolate	Recombinant	Details	Advances in the genotypic diagnosis of cytomegalovirus antiviral drug resistance. (Apr 2020)

Mutant	Resistances
A594E	Ganciclovir: Intermediate level resistance
A594G	Ganciclovir: High level resistance
A594P	Ganciclovir: High level resistance
A594P	Maribavir: No resistance
A594T	Ganciclovir: High level resistance
A594T	Maribavir: No resistance
A594V	Filociclovir: Range of values between Low level resistance and Intermediate level resistance
A594V	Maribavir: No resistance
A594V	Ganciclovir: High level resistance