Codex_V5

Filociclovir

Short name: CPV
Chembl ID: CHEMBL265948
SMILES (Simplified Molecular Input Line Entry System): C1C(=CN2C=NC3=C2N=C(NC3=O)N)C1(CO)CO

Mutant	Gene	Type	Virus	EC50 ratio	Phenotype	Assay	Reference
M460I	UL97	SNP	Human betaherpesvirus 5	12.00	High level resistance	Details	Cytomegalovirus UL97 mutations affecting cyclopropavir and ganciclovir susceptibility. (Jan 2011)
M460V	UL97	SNP	Human betaherpesvirus 5	4.00	Intermediate level resistance	Details	Cytomegalovirus UL97 mutations affecting cyclopropavir and ganciclovir susceptibility. (Jan 2011)
H520Q	UL97	SNP	Human betaherpesvirus 5	5.00-20.00	Range of values of High level resistance	Details	Cytomegalovirus UL97 mutations affecting cyclopropavir and ganciclovir susceptibility. (Jan 2011)
C592G	UL97	SNP	Human betaherpesvirus 5	2.20-4.90	Range of values between Low level resistance and Intermediate level resistance	Details	Advances in the genotypic diagnosis of cytomegalovirus antiviral drug resistance. (Apr 2020)
A594V	UL97	SNP	Human betaherpesvirus 5	2.20-4.90	Range of values between Low level resistance and Intermediate level resistance	Details	Advances in the genotypic diagnosis of cytomegalovirus antiviral drug resistance. (Apr 2020)
L595S	UL97	SNP	Human betaherpesvirus 5	<2.20	No more than Low level resistance	Details	Advances in the genotypic diagnosis of cytomegalovirus antiviral drug resistance. (Apr 2020)
C603W	UL97	SNP	Human betaherpesvirus 5	2.20-4.90	Range of values between Low level resistance and Intermediate level resistance	Details	Advances in the genotypic diagnosis of cytomegalovirus antiviral drug resistance. (Apr 2020)