Codex_V5

Brincidofovir

Short name: BCV
Chembl ID: CHEMBL203321
SMILES (Simplified Molecular Input Line Entry System): CCCCCCCCCCCCCCCCOCCCOP(=O)(COC(CN1C=CC(=NC1=O)N)CO)O

Mutant	Gene	Type	Virus	EC50 ratio	Phenotype	Assay	Reference
E303G	UL54	SNP	Human betaherpesvirus 5	11.00	High level resistance	Details	Novel Cytomegalovirus UL54 DNA Polymerase Gene Mutations Selected In Vitro That Confer Brincidofovir Resistance. (Jun 2016)
E303D	UL54	SNP	Human betaherpesvirus 5	9.70	High level resistance	Details	Novel Cytomegalovirus UL54 DNA Polymerase Gene Mutations Selected In Vitro That Confer Brincidofovir Resistance. (Jun 2016)
N408K	UL54	SNP	Human betaherpesvirus 5	11.00	High level resistance	Details	Novel Cytomegalovirus UL54 DNA Polymerase Gene Mutations Selected In Vitro That Confer Brincidofovir Resistance. (Jun 2016)
D413del	UL54	in/del	Human betaherpesvirus 5	5.20	High level resistance	Details	Novel Cytomegalovirus UL54 DNA Polymerase Gene Mutations Selected In Vitro That Confer Brincidofovir Resistance. (Jun 2016)
D413Y	UL54	SNP	Human betaherpesvirus 5	6.00	High level resistance	Details	Novel Cytomegalovirus UL54 DNA Polymerase Gene Mutations Selected In Vitro That Confer Brincidofovir Resistance. (Jun 2016)
V812L	UL54	SNP	Human betaherpesvirus 5	2.40	Low level resistance	Details	Novel Cytomegalovirus UL54 DNA Polymerase Gene Mutations Selected In Vitro That Confer Brincidofovir Resistance. (Jun 2016)