CHARMD

TOP

• Mutant: N408S
• Gene: UL54
• Virus: Human betaherpesvirus 5
• Strain:
• Reference: Novel DNA polymerase mutations conferring cytomegalovirus resistance: input of BAC-recombinant phenotyping and 3D model. (Apr 2013)


• Antiviral: Ganciclovir
• EC50 ratio: 3.10
• Phenotype: Intermediate level resistance
• Passage: N/A
• Source: N/A
• Marker: Recombinant


• Details:
  • PRA, ELISA tests, flow cytometry and DNA-DNA hybridization assays, quantitative real-time PCR, reporter cell lines, polymerase biochemical assays, marker transfer


• Observations:
  • Mutation fr?quemment retrouv?e chez les patients re?evant des CS h?matopo?etiques