Codex_V5

C592G

Antiviral	EC50 ratio	Phenotype	Source	Marker	Assay	Reference
Filociclovir	2.20-4.90	Range of values between Low level resistance and Intermediate level resistance	Laboratory strain, Clinical Isolate	Recombinant	Details	Advances in the genotypic diagnosis of cytomegalovirus antiviral drug resistance. (Apr 2020)
Maribavir	0.78	No resistance	Laboratory strain, Clinical Isolate	Recombinant	Details	Ganciclovir and maribavir cross-resistance revisited: Relative drug susceptibilities of canonical cytomegalovirus mutants. (Feb 2024)
Ganciclovir	3.20	Intermediate level resistance	Laboratory strain, Clinical Isolate	Recombinant	Details	Ganciclovir and maribavir cross-resistance revisited: Relative drug susceptibilities of canonical cytomegalovirus mutants. (Feb 2024)
Ganciclovir	3.00	Intermediate level resistance	Clinical Isolate		Details	Foscarnet resistance mutations mapping to atypical domains of the cytomegalovirus DNA polymerase gene. (Feb 2017)
Ganciclovir	3.10	Intermediate level resistance	Clinical Isolate		Details	Foscarnet resistance mutations mapping to atypical domains of the cytomegalovirus DNA polymerase gene. (Feb 2017)
Ganciclovir	3.10	Intermediate level resistance	Clinical Isolate		Details	Drug Resistance Mutations and Associated Phenotypes Detected in Clinical Trials of Maribavir for Treatment of Cytomegalovirus Infection. (Sep 2022)

Mutant	Resistances
C592F	Ganciclovir: High level resistance