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Last update : Wed 22 May 2024
TOP
UL27
Virus:
Human betaherpesvirus 5
Filter:
Mutant
Antiviral
EC50 ratio
Phenotype
Assay
Reference
Mutations:
P10L
Natural polymorphism
Details
Conserved domains and structure prediction of human cytomegalovirus UL27 protein. ( 2009)
L11P
Natural polymorphism
Details
Conserved domains and structure prediction of human cytomegalovirus UL27 protein. ( 2009)
P12L
Natural polymorphism
Details
Conserved domains and structure prediction of human cytomegalovirus UL27 protein. ( 2009)
E22STOP
Maribavir
2.00
Low level resistance
Details
Diverse cytomegalovirus UL27 mutations adapt to loss of viral UL97 kinase activity under maribavir. (Jan 2009)
A58T
Natural polymorphism
Details
Conserved domains and structure prediction of human cytomegalovirus UL27 protein. ( 2009)
D81N
Natural polymorphism
Details
Conserved domains and structure prediction of human cytomegalovirus UL27 protein. ( 2009)
A83V
Natural polymorphism
Details
Conserved domains and structure prediction of human cytomegalovirus UL27 protein. ( 2009)
A84P
Natural polymorphism
Details
Conserved domains and structure prediction of human cytomegalovirus UL27 protein. ( 2009)
A84V
Natural polymorphism
Details
Conserved domains and structure prediction of human cytomegalovirus UL27 protein. ( 2009)
K90R
Natural polymorphism
Details
Conserved domains and structure prediction of human cytomegalovirus UL27 protein. ( 2009)
H97R
Natural polymorphism
Details
Conserved domains and structure prediction of human cytomegalovirus UL27 protein. ( 2009)
L133I
Natural polymorphism
Details
Conserved domains and structure prediction of human cytomegalovirus UL27 protein. ( 2009)
A134T
Natural polymorphism
Details
Conserved domains and structure prediction of human cytomegalovirus UL27 protein. ( 2009)
W153R
Maribavir
1.70
No resistance
Details
Diverse cytomegalovirus UL27 mutations adapt to loss of viral UL97 kinase activity under maribavir. (Jan 2009)
L193F
Maribavir
2.60
Low level resistance
Details
Diverse cytomegalovirus UL27 mutations adapt to loss of viral UL97 kinase activity under maribavir. (Jan 2009)
C218del
Maribavir
2.50
Low level resistance
Details
Diverse cytomegalovirus UL27 mutations adapt to loss of viral UL97 kinase activity under maribavir. (Jan 2009)
E229D
Natural polymorphism
Details
Conserved domains and structure prediction of human cytomegalovirus UL27 protein. ( 2009)
R233S
Maribavir
Details
Mutations in the human cytomegalovirus UL27 gene that confer resistance to maribavir. (Jul 2004)
A269T
Maribavir
2.00
Low level resistance
Details
Diverse cytomegalovirus UL27 mutations adapt to loss of viral UL97 kinase activity under maribavir. (Jan 2009)
N289D
Natural polymorphism
Details
Conserved domains and structure prediction of human cytomegalovirus UL27 protein. ( 2009)
D294N
Natural polymorphism
Details
Conserved domains and structure prediction of human cytomegalovirus UL27 protein. ( 2009)
D294G
Natural polymorphism
Details
Conserved domains and structure prediction of human cytomegalovirus UL27 protein. ( 2009)
H297Y
Natural polymorphism
Details
Conserved domains and structure prediction of human cytomegalovirus UL27 protein. ( 2009)
D298G
Natural polymorphism
Details
Conserved domains and structure prediction of human cytomegalovirus UL27 protein. ( 2009)
N300G
Natural polymorphism
Details
Conserved domains and structure prediction of human cytomegalovirus UL27 protein. ( 2009)
301-311del
Maribavir
3.10
Intermediate level resistance
Details
Diverse cytomegalovirus UL27 mutations adapt to loss of viral UL97 kinase activity under maribavir. (Jan 2009)
P307L
Natural polymorphism
Details
Conserved domains and structure prediction of human cytomegalovirus UL27 protein. ( 2009)
V310A
Natural polymorphism
Details
Conserved domains and structure prediction of human cytomegalovirus UL27 protein. ( 2009)
H313Y
Natural polymorphism
Details
Conserved domains and structure prediction of human cytomegalovirus UL27 protein. ( 2009)
L335P
Maribavir
23.00
High level resistance
Details
Resistance of human cytomegalovirus to D- and L-ribosyl benzimidazoles as a tool to identify potential targets for antiviral drugs. (May-Aug 2003)
D351N
Natural polymorphism
Details
Conserved domains and structure prediction of human cytomegalovirus UL27 protein. ( 2009)
V353E
Maribavir
2.10
Low level resistance
Details
Diverse cytomegalovirus UL27 mutations adapt to loss of viral UL97 kinase activity under maribavir. (Jan 2009)
W362R
Maribavir
1.90
No resistance
Details
Mutations in the human cytomegalovirus UL27 gene that confer resistance to maribavir. (Jul 2004)
W362STOP
Maribavir
2.20
Low level resistance
Details
Diverse cytomegalovirus UL27 mutations adapt to loss of viral UL97 kinase activity under maribavir. (Jan 2009)
S363W
Natural polymorphism
Details
Conserved domains and structure prediction of human cytomegalovirus UL27 protein. ( 2009)
I367V
Natural polymorphism
Details
Conserved domains and structure prediction of human cytomegalovirus UL27 protein. ( 2009)
G421E
Natural polymorphism
Details
Conserved domains and structure prediction of human cytomegalovirus UL27 protein. ( 2009)
L426F
Maribavir
2.20
Low level resistance
Details
Diverse cytomegalovirus UL27 mutations adapt to loss of viral UL97 kinase activity under maribavir. (Jan 2009)
R465C
Natural polymorphism
Details
Conserved domains and structure prediction of human cytomegalovirus UL27 protein. ( 2009)
T519A
Natural polymorphism
Details
Conserved domains and structure prediction of human cytomegalovirus UL27 protein. ( 2009)
A520V
Natural polymorphism
Details
Conserved domains and structure prediction of human cytomegalovirus UL27 protein. ( 2009)
R531Q
Natural polymorphism
Details
Conserved domains and structure prediction of human cytomegalovirus UL27 protein. ( 2009)
H557Q
Natural polymorphism
Details
Conserved domains and structure prediction of human cytomegalovirus UL27 protein. ( 2009)
A558V
Natural polymorphism
Details
Conserved domains and structure prediction of human cytomegalovirus UL27 protein. ( 2009)
A565T
Natural polymorphism
Details
Conserved domains and structure prediction of human cytomegalovirus UL27 protein. ( 2009)
P571T
Natural polymorphism
Details
Conserved domains and structure prediction of human cytomegalovirus UL27 protein. ( 2009)
H606Y
Natural polymorphism
Details
Conserved domains and structure prediction of human cytomegalovirus UL27 protein. ( 2009)