CHARMD

Comprehensive Herpesviruses Antiviral drug Resistance Mutation Database


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    UL27

    Mutations:

    Mutant Antiviral EC50 ratio Phenotype Assay Reference
    P10L Natural polymorphism Details Conserved domains and structure prediction of human cytomegalovirus UL27 protein. ( 2009)
    L11P Natural polymorphism Details Conserved domains and structure prediction of human cytomegalovirus UL27 protein. ( 2009)
    P12L Natural polymorphism Details Conserved domains and structure prediction of human cytomegalovirus UL27 protein. ( 2009)
    E22STOP Maribavir 2.00 Low level resistance Details Diverse cytomegalovirus UL27 mutations adapt to loss of viral UL97 kinase activity under maribavir. (Jan 2009)
    A58T Natural polymorphism Details Conserved domains and structure prediction of human cytomegalovirus UL27 protein. ( 2009)
    D81N Natural polymorphism Details Conserved domains and structure prediction of human cytomegalovirus UL27 protein. ( 2009)
    A83V Natural polymorphism Details Conserved domains and structure prediction of human cytomegalovirus UL27 protein. ( 2009)
    A84P Natural polymorphism Details Conserved domains and structure prediction of human cytomegalovirus UL27 protein. ( 2009)
    A84V Natural polymorphism Details Conserved domains and structure prediction of human cytomegalovirus UL27 protein. ( 2009)
    K90R Natural polymorphism Details Conserved domains and structure prediction of human cytomegalovirus UL27 protein. ( 2009)
    H97R Natural polymorphism Details Conserved domains and structure prediction of human cytomegalovirus UL27 protein. ( 2009)
    L133I Natural polymorphism Details Conserved domains and structure prediction of human cytomegalovirus UL27 protein. ( 2009)
    A134T Natural polymorphism Details Conserved domains and structure prediction of human cytomegalovirus UL27 protein. ( 2009)
    W153R Maribavir 1.70 No resistance Details Diverse cytomegalovirus UL27 mutations adapt to loss of viral UL97 kinase activity under maribavir. (Jan 2009)
    L193F Maribavir 2.60 Low level resistance Details Diverse cytomegalovirus UL27 mutations adapt to loss of viral UL97 kinase activity under maribavir. (Jan 2009)
    C218del Maribavir 2.50 Low level resistance Details Diverse cytomegalovirus UL27 mutations adapt to loss of viral UL97 kinase activity under maribavir. (Jan 2009)
    E229D Natural polymorphism Details Conserved domains and structure prediction of human cytomegalovirus UL27 protein. ( 2009)
    R233S Maribavir Details Mutations in the human cytomegalovirus UL27 gene that confer resistance to maribavir. (Jul 2004)
    R233S Maribavir 0.20 Possible hypersensitivity, no resistance Details Antiviral activity of maribavir in combination with other drugs active against human cytomegalovirus. (Sep 2018)
    A269T Maribavir 2.00 Low level resistance Details Diverse cytomegalovirus UL27 mutations adapt to loss of viral UL97 kinase activity under maribavir. (Jan 2009)
    N289D Natural polymorphism Details Conserved domains and structure prediction of human cytomegalovirus UL27 protein. ( 2009)
    D294N Natural polymorphism Details Conserved domains and structure prediction of human cytomegalovirus UL27 protein. ( 2009)
    D294G Natural polymorphism Details Conserved domains and structure prediction of human cytomegalovirus UL27 protein. ( 2009)
    H297Y Natural polymorphism Details Conserved domains and structure prediction of human cytomegalovirus UL27 protein. ( 2009)
    D298G Natural polymorphism Details Conserved domains and structure prediction of human cytomegalovirus UL27 protein. ( 2009)
    N300G Natural polymorphism Details Conserved domains and structure prediction of human cytomegalovirus UL27 protein. ( 2009)
    301-311del Maribavir 3.10 Intermediate level resistance Details Diverse cytomegalovirus UL27 mutations adapt to loss of viral UL97 kinase activity under maribavir. (Jan 2009)
    P307L Natural polymorphism Details Conserved domains and structure prediction of human cytomegalovirus UL27 protein. ( 2009)
    V310A Natural polymorphism Details Conserved domains and structure prediction of human cytomegalovirus UL27 protein. ( 2009)
    H313Y Natural polymorphism Details Conserved domains and structure prediction of human cytomegalovirus UL27 protein. ( 2009)
    L335P Maribavir 23.00 High level resistance Details Resistance of human cytomegalovirus to D- and L-ribosyl benzimidazoles as a tool to identify potential targets for antiviral drugs. (May-Aug 2003)
    G344D Maribavir 0.90 No resistance Details Drug Resistance Mutations and Associated Phenotypes Detected in Clinical Trials of Maribavir for Treatment of Cytomegalovirus Infection. (Sep 2022)
    D351N Natural polymorphism Details Conserved domains and structure prediction of human cytomegalovirus UL27 protein. ( 2009)
    V353E Maribavir 2.10 Low level resistance Details Diverse cytomegalovirus UL27 mutations adapt to loss of viral UL97 kinase activity under maribavir. (Jan 2009)
    W362R Maribavir 1.90 No resistance Details Mutations in the human cytomegalovirus UL27 gene that confer resistance to maribavir. (Jul 2004)
    W362STOP Maribavir 2.20 Low level resistance Details Diverse cytomegalovirus UL27 mutations adapt to loss of viral UL97 kinase activity under maribavir. (Jan 2009)
    S363W Natural polymorphism Details Conserved domains and structure prediction of human cytomegalovirus UL27 protein. ( 2009)
    I367V Natural polymorphism Details Conserved domains and structure prediction of human cytomegalovirus UL27 protein. ( 2009)
    G421E Natural polymorphism Details Conserved domains and structure prediction of human cytomegalovirus UL27 protein. ( 2009)
    L426F Maribavir 2.20 Low level resistance Details Diverse cytomegalovirus UL27 mutations adapt to loss of viral UL97 kinase activity under maribavir. (Jan 2009)
    R465C Natural polymorphism Details Conserved domains and structure prediction of human cytomegalovirus UL27 protein. ( 2009)
    T519A Natural polymorphism Details Conserved domains and structure prediction of human cytomegalovirus UL27 protein. ( 2009)
    A520V Natural polymorphism Details Conserved domains and structure prediction of human cytomegalovirus UL27 protein. ( 2009)
    R531Q Natural polymorphism Details Conserved domains and structure prediction of human cytomegalovirus UL27 protein. ( 2009)
    H557Q Natural polymorphism Details Conserved domains and structure prediction of human cytomegalovirus UL27 protein. ( 2009)
    A558V Natural polymorphism Details Conserved domains and structure prediction of human cytomegalovirus UL27 protein. ( 2009)
    A565T Natural polymorphism Details Conserved domains and structure prediction of human cytomegalovirus UL27 protein. ( 2009)
    P571T Natural polymorphism Details Conserved domains and structure prediction of human cytomegalovirus UL27 protein. ( 2009)
    H606Y Natural polymorphism Details Conserved domains and structure prediction of human cytomegalovirus UL27 protein. ( 2009)

    Tilloy et al., 2024
    Interdeposit Digital Number: IDDN.FR.001.420004.000.S.X.2024.000.31230