CHARMD

Comprehensive Herpesviruses Antiviral drug Resistance Mutation Database


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    UL27

    Mutations:

    Mutant Antiviral EC50 ratio Phenotype Assay Reference
    P10L N/A N/A Natural polymorphism Details Conserved domains and structure prediction of human cytomegalovirus UL27 protein. ( 2009)
    L11P N/A N/A Natural polymorphism Details Conserved domains and structure prediction of human cytomegalovirus UL27 protein. ( 2009)
    P12L N/A N/A Natural polymorphism Details Conserved domains and structure prediction of human cytomegalovirus UL27 protein. ( 2009)
    E22STOP Maribavir 2.00 Low level resistance Details Diverse cytomegalovirus UL27 mutations adapt to loss of viral UL97 kinase activity under maribavir. (Jan 2009)
    A58T N/A N/A Natural polymorphism Details Conserved domains and structure prediction of human cytomegalovirus UL27 protein. ( 2009)
    D81N N/A N/A Natural polymorphism Details Conserved domains and structure prediction of human cytomegalovirus UL27 protein. ( 2009)
    A83V N/A N/A Natural polymorphism Details Conserved domains and structure prediction of human cytomegalovirus UL27 protein. ( 2009)
    A84P N/A N/A Natural polymorphism Details Conserved domains and structure prediction of human cytomegalovirus UL27 protein. ( 2009)
    A84V N/A N/A Natural polymorphism Details Conserved domains and structure prediction of human cytomegalovirus UL27 protein. ( 2009)
    K90R N/A N/A Natural polymorphism Details Conserved domains and structure prediction of human cytomegalovirus UL27 protein. ( 2009)
    H97R N/A N/A Natural polymorphism Details Conserved domains and structure prediction of human cytomegalovirus UL27 protein. ( 2009)
    L133I N/A N/A Natural polymorphism Details Conserved domains and structure prediction of human cytomegalovirus UL27 protein. ( 2009)
    A134T N/A N/A Natural polymorphism Details Conserved domains and structure prediction of human cytomegalovirus UL27 protein. ( 2009)
    W153R Maribavir 1.70 No resistance Details Diverse cytomegalovirus UL27 mutations adapt to loss of viral UL97 kinase activity under maribavir. (Jan 2009)
    L193F Maribavir 2.60 Low level resistance Details Diverse cytomegalovirus UL27 mutations adapt to loss of viral UL97 kinase activity under maribavir. (Jan 2009)
    C218del Maribavir 2.50 Low level resistance Details Diverse cytomegalovirus UL27 mutations adapt to loss of viral UL97 kinase activity under maribavir. (Jan 2009)
    E229D N/A N/A Natural polymorphism Details Conserved domains and structure prediction of human cytomegalovirus UL27 protein. ( 2009)
    R233S Maribavir N/A Details Mutations in the human cytomegalovirus UL27 gene that confer resistance to maribavir. (Jul 2004)
    A269T Maribavir 2.00 Low level resistance Details Diverse cytomegalovirus UL27 mutations adapt to loss of viral UL97 kinase activity under maribavir. (Jan 2009)
    N289D N/A N/A Natural polymorphism Details Conserved domains and structure prediction of human cytomegalovirus UL27 protein. ( 2009)
    D294N N/A N/A Natural polymorphism Details Conserved domains and structure prediction of human cytomegalovirus UL27 protein. ( 2009)
    D294G N/A N/A Natural polymorphism Details Conserved domains and structure prediction of human cytomegalovirus UL27 protein. ( 2009)
    H297Y N/A N/A Natural polymorphism Details Conserved domains and structure prediction of human cytomegalovirus UL27 protein. ( 2009)
    D298G N/A N/A Natural polymorphism Details Conserved domains and structure prediction of human cytomegalovirus UL27 protein. ( 2009)
    N300G N/A N/A Natural polymorphism Details Conserved domains and structure prediction of human cytomegalovirus UL27 protein. ( 2009)
    301-311del Maribavir 3.10 Intermediate level resistance Details Diverse cytomegalovirus UL27 mutations adapt to loss of viral UL97 kinase activity under maribavir. (Jan 2009)
    P307L N/A N/A Natural polymorphism Details Conserved domains and structure prediction of human cytomegalovirus UL27 protein. ( 2009)
    V310A N/A N/A Natural polymorphism Details Conserved domains and structure prediction of human cytomegalovirus UL27 protein. ( 2009)
    H313Y N/A N/A Natural polymorphism Details Conserved domains and structure prediction of human cytomegalovirus UL27 protein. ( 2009)
    L335P Maribavir 23.00 High level resistance Details Resistance of human cytomegalovirus to D- and L-ribosyl benzimidazoles as a tool to identify potential targets for antiviral drugs. (May-Aug 2003)
    D351N N/A N/A Natural polymorphism Details Conserved domains and structure prediction of human cytomegalovirus UL27 protein. ( 2009)
    V353E Maribavir 2.10 Low level resistance Details Diverse cytomegalovirus UL27 mutations adapt to loss of viral UL97 kinase activity under maribavir. (Jan 2009)
    W362R Maribavir 1.90 No resistance Details Mutations in the human cytomegalovirus UL27 gene that confer resistance to maribavir. (Jul 2004)
    W362STOP Maribavir 2.20 Low level resistance Details Diverse cytomegalovirus UL27 mutations adapt to loss of viral UL97 kinase activity under maribavir. (Jan 2009)
    S363W N/A N/A Natural polymorphism Details Conserved domains and structure prediction of human cytomegalovirus UL27 protein. ( 2009)
    I367V N/A N/A Natural polymorphism Details Conserved domains and structure prediction of human cytomegalovirus UL27 protein. ( 2009)
    G421E N/A N/A Natural polymorphism Details Conserved domains and structure prediction of human cytomegalovirus UL27 protein. ( 2009)
    L426F Maribavir 2.20 Low level resistance Details Diverse cytomegalovirus UL27 mutations adapt to loss of viral UL97 kinase activity under maribavir. (Jan 2009)
    R465C N/A N/A Natural polymorphism Details Conserved domains and structure prediction of human cytomegalovirus UL27 protein. ( 2009)
    T519A N/A N/A Natural polymorphism Details Conserved domains and structure prediction of human cytomegalovirus UL27 protein. ( 2009)
    A520V N/A N/A Natural polymorphism Details Conserved domains and structure prediction of human cytomegalovirus UL27 protein. ( 2009)
    R531Q N/A N/A Natural polymorphism Details Conserved domains and structure prediction of human cytomegalovirus UL27 protein. ( 2009)
    H557Q N/A N/A Natural polymorphism Details Conserved domains and structure prediction of human cytomegalovirus UL27 protein. ( 2009)
    A558V N/A N/A Natural polymorphism Details Conserved domains and structure prediction of human cytomegalovirus UL27 protein. ( 2009)
    A565T N/A N/A Natural polymorphism Details Conserved domains and structure prediction of human cytomegalovirus UL27 protein. ( 2009)
    P571T N/A N/A Natural polymorphism Details Conserved domains and structure prediction of human cytomegalovirus UL27 protein. ( 2009)
    H606Y N/A N/A Natural polymorphism Details Conserved domains and structure prediction of human cytomegalovirus UL27 protein. ( 2009)

    Tilloy et al., 2024
    Interdeposit Digital Number: IDDN.FR.001.420004.000.S.X.2024.000.31230