Codex_V5

Biron KK

References:

Rank: 4 - Single amino acid changes in the DNA polymerase confer foscarnet resistance and slow-growth phenotype, while mutations in the UL97-encoded phosphotransferase confer ganciclovir resistance in three double-resistant human cytomegalovirus strains recovered from patients with AIDS.(Mar 1996)
Rank: 5 - Emergence of a ganciclovir-resistant human cytomegalovirus strain with a new UL97 mutation in an AIDS patient.(May 1998)
Rank: 5 - Mutations in the human cytomegalovirus UL27 gene that confer resistance to maribavir.(Jul 2004)
Rank: 6 - A protein kinase homologue controls phosphorylation of ganciclovir in human cytomegalovirus-infected cells.(Sep 1992)
Rank: 6 - A three-nucleotide deletion in the UL97 open reading frame is responsible for the ganciclovir resistance of a human cytomegalovirus clinical isolate.(Feb 1995)
Rank: 7 - Longitudinal observations on mutations conferring ganciclovir resistance in patients with acquired immunodeficiency syndrome and cytomegalovirus retinitis: The Cytomegalovirus and Viral Resistance Study Group Report Number 8.(Nov 2001)

Mutations:

Mutant	Gene	Virus	Reference
R233S	UL27	Human betaherpesvirus 5	Mutations in the human cytomegalovirus UL27 gene that confer resistance to maribavir. (Jul 2004)
W362R	UL27	Human betaherpesvirus 5	Mutations in the human cytomegalovirus UL27 gene that confer resistance to maribavir. (Jul 2004)
V715M	UL54	Human betaherpesvirus 5	Single amino acid changes in the DNA polymerase confer foscarnet resistance and slow-growth phenotype, while mutations in the UL97-encoded phosphotransferase confer ganciclovir resistance in three double-resistant human cytomegalovirus strains recovered from patients with AIDS. (Mar 1996)
V715M	UL54	Human betaherpesvirus 5	Single amino acid changes in the DNA polymerase confer foscarnet resistance and slow-growth phenotype, while mutations in the UL97-encoded phosphotransferase confer ganciclovir resistance in three double-resistant human cytomegalovirus strains recovered from patients with AIDS. (Mar 1996)
V715M	UL54	Human betaherpesvirus 5	Single amino acid changes in the DNA polymerase confer foscarnet resistance and slow-growth phenotype, while mutations in the UL97-encoded phosphotransferase confer ganciclovir resistance in three double-resistant human cytomegalovirus strains recovered from patients with AIDS. (Mar 1996)
591-594del	UL97	Human betaherpesvirus 5	A protein kinase homologue controls phosphorylation of ganciclovir in human cytomegalovirus-infected cells. (Sep 1992)
L595del	UL97	Human betaherpesvirus 5	A three-nucleotide deletion in the UL97 open reading frame is responsible for the ganciclovir resistance of a human cytomegalovirus clinical isolate. (Feb 1995)
G598S	UL97	Human betaherpesvirus 5	Emergence of a ganciclovir-resistant human cytomegalovirus strain with a new UL97 mutation in an AIDS patient. (May 1998)
L600del	UL97	Human betaherpesvirus 5	Longitudinal observations on mutations conferring ganciclovir resistance in patients with acquired immunodeficiency syndrome and cytomegalovirus retinitis: The Cytomegalovirus and Viral Resistance Study Group Report Number 8. (Nov 2001)