Codex_V5

Longitudinal observations on mutations conferring ganciclovir resistance in patients with acquired immunodeficiency syndrome and cytomegalovirus retinitis: The Cytomegalovirus and Viral Resistance Study Group Report Number 8.

Pubmed_id: 11704031
Journal: American journal of ophthalmology
Genbank_id: No known Genbank_id
Date: Nov 2001
Volume: 132
Issue: 5
Pages: 700-10
Author(s): Jabs DA, Martin BK, Forman MS, Dunn JP, Davis JL, Weinberg DV, Biron KK, Baldanti F, Hu H,

Abstract: Resistance-conferring mutations in the cytomegalovirus genome emerge and may persist when the selective pressure for resistance is maintained. Some patients appear to harbor complex subpopulations of virus with different mutations and different levels of phenotypic resistance. Changes in therapy may result in a shift in virus population and changes in the cytomegalovirus genotype identified.

Mutant	Gene	Virus	Antiviral	EC50 ratio	Phenotype
L600del	UL97	Human betaherpesvirus 5	Ganciclovir	1.90	No resistance