CHARMD

Comprehensive Herpesviruses Antiviral drug Resistance Mutation Database


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    L595del

    Antiviral assays:

    Antiviral EC50 ratio Phenotype Strain Source Marker Assay Reference
    Ganciclovir 13.30 High level resistance Laboratory strain, Clinical Isolate Recombinant Details A three-nucleotide deletion in the UL97 open reading frame is responsible for the ganciclovir resistance of a human cytomegalovirus clinical isolate. (Feb 1995)

    Mutations at the same locus:

    Mutant Resistances
    595-603del Ganciclovir: High level resistance
    L595F Maribavir: No resistance
    L595F Ganciclovir: High level resistance
    L595S Filociclovir: No more than Low level resistance
    L595S Maribavir: No resistance
    L595S Ganciclovir: High level resistance
    L595W Maribavir: No resistance
    L595W Ganciclovir: High level resistance


    Tilloy et al., 2024
    Interdeposit Digital Number: IDDN.FR.001.420004.000.S.X.2024.000.31230