First structural elucidation of the human ABCC4/MRP4 exporter in lipid bilayers

The ABCC4/MRP4 exporter has a clinical impact on membrane transport of a broad range of xenobiotics. It is expressed at key locations for drug disposition or effects such as in the liver, the kidney and blood cells. Several polymorphisms and mutations (e.g., p.Gly187Trp) leading to MRP4 [...]

Review: Pharmacokinetic models to assist the prescriber in choosing the best tacrolimus dose

Due to a high inter-individual variability in its pharmacokinetics, tacrolimus dose individualization is mandatory. Even though the expert opinion has defined the area under the curve (AUC) as the best marker to use when performing dose adjustment of tacrolimus, most centres only use trough [...]

In silico pharmacology: Drug membrane partitioning and crossing

Over the past decade, molecular dynamics (MD) simulations have become particularly powerful to rationalize drug insertion and partitioning in lipid bilayers. MD simulations efficiently support experimental evidences, with a comprehensive understanding of molecular interactions driving insertion [...]

Roland Lawson récompensé pour la pédagogie en ligne

À l’occasion du 22e congrès annuel de la Société Française de Pharmacologie et de Thérapeutique(SFPT), Roland Lawson (post-doctorant chargé de cours de pharmacologie à la faculté de Pharmacie) a obtenu le prix du meilleur poster modéré de la session pharmacovigilance. Le travail présenté [...]

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INSERM News

Organ transplantation repairs broken human being. It is among the most promising techniques to repair any single damaged part of a body in the near future. The INSERM U1248 IPPRITT (Individual Profiling and Prevention of Risks with Immunosuppressive Therapies and Transplantation) unit is part of the hospital-university “Survival oPtimization in ORgan Transplantation” (FHU SUPORT) federation.

Owing to its translational research strategy, as led by clinicians, biologists, pharmacologists and physical-chemists, IPPRITT has developed both basic and clinical research programmes and tools to improve transplant patient care. The findings (mainly in pharmacology) are transferred to the clinics, aiming at the development of personalized medicine.

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