Permanent researcher INSERM
Team 2MB2C – Responsible for the ‘Mechanisms of genetic instability underlying tumour transformation and progression in chronic lymphocytic leukaemia’ axis.
Structure, lesion and repair of the tumour B cell genome in chronic lymphocytic leukaemia: deciphering to propose new therapeutic approaches.
Office 137 CBRS
+33 519 564 210
sophie.peron@unilim.fr
Research activity
We are studying the fundamental mechanisms involved in the tumour transformation of B cells, particularly in chronic lymphocytic leukaemia (CLL) and non-Hodgkin’s B lymphomas associated with MYC overexpression. Our work focuses on the mechanisms that normally ensure the maintenance of genomic stability, from nuclear organisation to DNA repair processes.
Professional background
Since 2019: Head of the ‘Mechanisms of genetic instability underlying tumour transformation and evolution in chronic lymphocytic leukaemia’ axis.
2014-2018: Researcher in Prof. Cogné’s team, CRIBL Laboratory.
Since 2013: INSERM research fellow.
2009-2013: Post-doctorate at the UMR CNRS 7276 CRIBL laboratory.
2004-2008: PhD in Immunology, Université Paris VII and Inserm U768 (Director: Pr A. Fischer), Hôpital Necker, Paris. Title of thesis: ‘Molecular characterization of inherited immunoglobulin class switch recombination deficiencies’, Supervisor: Dr Anne Durandy.
2003-2004: DEA (post-graduate diploma) in immunology, Université Paris VI and Institut Pasteur, Paris.
1999-2003: DEUG, Licence and Maîtrise in Biochemistry, specialising in immunology and microbial biochemistry, University of Poitiers.
Current projects
MYC-3DB: Study of the impact of MYC overexpression on the 3D organisation of chromatin and transcriptomic deregulation in B cells to better understand the pathophysiology of B cell cancers associated with MYC overexpression
Project leader: Sophie Peron
Funding: Comité de la Haute Vienne de la Ligue contre le cancer, Région Nouvelle Aquitaine, Institut Omegahealth, Université de Limoges and Cancéropôle Grand Sud Ouest.
Collaboration with Manuel Diaz Muñoz, INFINITY, Toulouse, Saïd Aoufouchi, Gustave Roussy, Villejuif and Biola Javierre, Josep Carreras Leukemia Research Institute, Barcelona.
PROMISE: use of the Omomyc mini protein to inhibit the survival and expansion of chronic lymphocytic leukaemia tumour cells.
Project leader: Sophie Peron.
Collaboration with Laura Soucek and Jonathan Whitfield, VHIO, Barcelona.
DALIPT: Deciphering genetic alterations in chronic lymphocytic leukaemia: implications for prognosis and therapeutic strategies.
Coordinators: Jasmine Chauzeix, Nathalie Gachard and Sophie Peron
Funding: Comité de la Haute Vienne de la Ligue contre le cancer.
EVOLLC: This project aims to understand how genomic instability influences the evolution of chronic lymphocytic leukaemia, by characterising specific sub-groups of patients and identifying new therapeutic targets.
Project leaders: Nathalie Gachard and Sophie Peron
Funding: Comité de la Haute Vienne de la Ligue contre le cancer.
Associate staff
Nathalie Gachard (PH ; Service d’Hématologie biologique)
David Rizzo (MCU-PH ; Service d’Hématologie biologique)
Jasmine Chauzeix (MCU-PH ; Service d’Hématologie biologique)
Anna Cracco, Master 2, 2025.
Alumni
Kenza Guiyedi, Master 2, 2023 ; PhD student, 2021-2024.
Milène Parquet, PhD student 2021-2024.
Maxime Roubinet, Master 2, 2024
Marie Lambert, Master 1,2023
Clément Farout, Master 1, 2023
Israa Al Jamal, PhD student 2019-2022.
Hend Boutouil, Master 2 , 2014 ; Doctorante, 2015-2018.
Ophélie Téteau, Master 1, 2016
Sharing
CSReport software (Boyer et al., J Immunol. 2017) enables analysis of high-throughput sequencing data from PCR products amplifying recombination junctions at the IgH locus.
CSReport requires the Python3 and Jupyter environments (preferably from an Anaconda distribution) with an updated Biopython package.
CSReport works with a custom reference (derived from NCBI sources) of a constant IgH locus sequence and annotations for human or mouse. The reference must be chosen according to the model organism.
The CSReport notebook file (ZIP archive) including the reference files is available on request by email.
Publications
-Guiyedi K, Parquet M, Al Jamal I, Ouk C, Téteau O, Vincent-Fabert C, Aoufouchi S, Roubinet M, Faumont N, Marchiol T, Boulin M, Rizzo D, Chauzeix J, Feuillard J, Gachard N, Peron S. Activated mature B cells undergo enforced Sµ-3’RRrec in the λ-c-MYC mouse model. PREPRINT (Version 1, 29 October 2024) available at Research Square [https://doi.org/10.21203/rs.3.rs-5331665/v1].
-Guiyedi* K, Parquet* M, Aoufouchi S, Chauzeix J, Rizzo D, Al Jamal I, Feuillard J, Gachard N, Peron S. Increased c-MYC expression associated with active IGH locus rearrangement: an emerging role for c-MYC in Chronic Lymphocytic Leukemia. Review, Cancers, (accepted, 29 October 2024).
-Parquet M, Guiyedi K, Pollet J, Al Jamal I, Roubinet M, Chauzeix J, Boulin M, Rizzo D, Feuillard J, Gachard N, Peron S. Sµ-3’RRrecHigh Chronic Lymphocytic Leukemia is associated with specific gene expression signature, activation-induced cMYC expression and sustained cell cycle entry. PREPRINT (Version 1, 19 August 2024) available at Research Square [https://doi.org/10.21203/rs.3.rs-4923370/v1].
-Al Jamal I, Parquet M, Guiyedi K, Aoufouchi S, Le Guillou M, Rizzo D, Pollet J, Dupont M, Boulin M, Faumont N, Boutouil H, Jardin F, Ruminy P, El Hamel C, Lerat J, Al Hamaoui S, Makdissy N, Feuillard J, Gachard N, Peron S. IGH 3’RR recombination uncovers a non-germinal center imprint and c-MYC-dependent IGH rearrangement in unmutated chronic lymphocytic leukemia. Haematologica. 2024 Feb 1;109(2):466-478. doi: 10.3324/haematol.2023.282897. IF: 10.1.
-Denis-Lagache N, Oblet C, Marchiol T, Baylet A, Têteau O, Dalloul I, Dalloul Z, Zawil L, Dézé O, Cook-Moreau J, Saintamand A, Boutouil H, Khamlichi AA, Carrion C, Péron S, Le Noir S, Laffleur B, Cogné M. Attempts to evaluate locus suicide recombination and its potential role in B cell negative selection in the mouse. Front Immunol. 2023 Jun 9;14:1155906. doi: 10.3389/fimmu.2023.1155906. eCollection 2023.
-Eldin P, Péron S, Galashevskaya A, Denis-Lagache N, Cogné M, Slupphaug G and Briant L. HIV-1 may evade antibody class switching via Vpr-mediated UNG2 degradation in bystander B cells – Journal of Translational Medicine, 2020.
-Boutouil H, Boyer F, Cook-Moreau J, Cogné M, Péron S. IgH locus suicide recombination does not depend on NHEJ in contrast to CSR in B cells. Cell Mol Immunol. 2019 Feb;16(2):201-202.
-Dalloul I, Boyer F, Dalloul Z, Pignarre A, Caron G, Fest T, Chatonnet F, Delaloy C, Durandy A, Jeannet R, Lereclus E, Boutouil H, Aldigier JC, Péron S, Le Noir S, Cook-Moreau J, Cogné M. Locus suicide recombination actively occurs on the functionally rearranged IgH allele in B-cells from inflamed human lymphoid tissues. PLoS Genet. 2019 Jun 14;15(6).
-Cresson C, Péron S, Jamrog L, Rouquié N, Prade N, Dubois M, Hébrard S, Lagarde S, Gerby B, Mancini SJC, Cogné M, Delabesse E, Delpy L, Broccardo C. PAX5A and PAX5B isoforms are both efficient to drive B cell differentiation. Oncotarget. 2018 Aug 28;9(67):32841-32854.
-Boyer F, Boutouil H, Dalloul I, Dalloul Z, Cook-Moreau J, Aldigier JC, Carrion C, Herve B, Scaon E, Cogné M, Péron S. CSReport: A New Computational Tool Designed for Automatic Analysis of Class Switch Recombination Junctions Sequenced by High-Throughput Sequencing. J Immunol. 2017 May 15;198(10):4148-4155.
-Srour N, Chemin G, Tinguely A, Ashi MO, Oruc Z, Péron S, Sirac C, Cogné M, Delpy L. A plasma cell differentiation quality control ablates B cell clones with biallelic Ig rearrangements and truncated Ig production. J Exp Med. 2016 Jan 11;213(1):109-22.
-Laffleur B, Duchez S, Tarte K, Denis-Lagache N, Péron S, Carrion C, Denizot Y, Cogné M. Self-Restrained B Cells Arise following Membrane IgE Expression. Cell Rep. 2015 Feb 17;10(6):900-909.
-Laffleur B, Denis-Lagache N, Péron S, Sirac C, Moreau J, Cogné M. AID-induced remodeling of immunoglobulin genes and B cell fate. Oncotarget. 2014 Mar 15;5(5):1118-31.
-Péron S, Laffleur B, Denis-Lagache N, Cook-Moreau J, Filloux M, Cogné M. [IgH locus suicide recombination, or when B cells surrender!]. Med Sci (Paris). 2012
-Péron S, Laffleur B, Denis-Lagache N, Cook-Moreau J, Tinguely A, Delpy L, Denizot Y, Pinaud E, Cogné M. AID-driven deletion causes immunoglobulin heavy chain locus suicide recombination in B cells. Science. 2012 May 18;336(6083):931-4.
-Tinguely A, Chemin G, Péron S, Sirac C, Reynaud S, Cogné M, Delpy L. Cross talk between immunoglobulin heavy-chain transcription and RNA surveillance during B cell development. Mol Cell Biol. 2012 Jan;32(1):107-17.
-Pinaud E, Marquet M, Fiancette R, Péron S, Vincent-Fabert C, Denizot Y, Cogné M. The IgH locus 3′ regulatory region: pulling the strings from behind. Adv Immunol. 2011;110:27-70.
-Péron S, Metin A, Gardès P, Alyanakian MA, Sheridan E, Kratz CP, Fischer A, Durandy A. Human PMS2 deficiency is associated with impaired immunoglobulin class switch recombination. J Exp Med. 2008 Oct 27;205(11):2465-72.
-Etzioni A, Ben-Barak A, Peron S, Durandy A. Ataxia-telangiectasia in twins presenting as autosomal recessive hyper-immunoglobulin M syndrome. Isr Med Assoc J. 2007 May;9(5):406-7.
-Durandy A, Taubenheim N, Peron S, Fischer A. Pathophysiology of B-cell intrinsic immunoglobulin class switch recombination deficiencies. Adv Immunol. 2007;94:275-306. Review.
-Péron S, Pan-Hammarstrom Q, Imai K, Du L, Taubenheim N, Sanal O, Marodi L, Bergelin-Besançon A, Benkerrou M, de Villartay JP, Fischer A, Revy P, Durandy A. A primary immunodeficiency characterized by defective immunoglobulin class switch recombination and impaired DNA repair. J Exp Med. 2007 May 14;204(5):1207-16.
-Durandy A, Peron S, Taubenheim N, Fischer A. Activation-induced cytidine deaminase: structure-function relationship as based on the study of mutants. Hum Mutat. 2006 Dec;27(12):1185-91. Review.
-Durandy A, Peron S, Fischer A. Hyper-IgM syndromes. Curr Opin Rheumatol. 2006 Jul;18(4):369-76. Review.
-Notarangelo LD, Lanzi G, Peron S, Durandy A. Defects of class-switch recombination. J Allergy Clin Immunol. 2006 Apr;117(4):855-64. Review.