COVID-19: What are the consequences of infection on different white blood cells?

The Molecular Mechanisms and Lymphomagenesis team led by Prof. Jean Feuillard (CRIBL Research Unit) as well as the Clinical Investigation Center of the Limoges University Hospital, presents the first study, with a follow-up over time, of the different white blood cells, or leukocytes, blood and their functional changes in COVID-19 patients with respiratory distress admitted to intensive care.

Contact : Jean Feuillard, PU-PH

 

Extract from the Press Release – June 18, 2020 :

COVID-19: What are the consequences of infection on different white blood cells?

“Led by Robin Jeannet, a research team from CRIBL (CNRS 7276 / Inserm 1262 / University of Limoges) and the Inserm 1435 clinical investigation center of the CHU de Limoges, led by Prof. Jean Feuillard and Dr Bruno François respectively, present the first study, with a follow-up over time, of the various white blood cells, or leukocytes, in the blood and their functional modifications in COVID-19 patients in respiratory distress admitted to intensive care.

Correlated with morbidity and mortality, COVID-19 is associated with marked lymphopenia. Lymphopenia is a decrease in the number of T lymphocytes – leukocytes that play a major role in the immune response.

Very few studies have characterized the consequences of this infection on the different subtypes of leukocytes. Selected by the medical journal Intensive Care Medicine, the fruit of this work reaffirms the expertise of the Limoges teams in sepsis ** and on questions relating to the players in the immune response – in B lymphomas, the main research theme of Prof Feuillard’s team, or in situations of external aggression, as here in the case of SARS-CoV-2.”

 

Find the full press release here.

 


France 3 Limousin – Article du 23/06/2020.

 


Le Populaire du Centre 23/06/2020.

 


Ouest france 24/06/2020.

 


CNRS Hebdo – édition du 18/06/2020.

 


INSB CNRS : Communiqué de presse CNRS du 18/06/2020

 


Jeannet R, Daix T, Formento R, Feuillard J, François B. Severe COVID-19 is associated with deep and sustained multifaceted cellular immunosuppression [published online ahead of print, 2020 Jun 8]. Intensive Care Med. 2020;1-3. doi:10.1007/s00134-020-06127-x