CHARMD

Comprehensive Herpesviruses Antiviral drug Resistance Mutation Database


  • TOP

    L595S

    Antiviral assays:

    Antiviral EC50 ratio Phenotype Strain Source Marker Assay Reference
    Filociclovir <2.20 No more than Low level resistance Laboratory strain, Clinical Isolate Recombinant Details Advances in the genotypic diagnosis of cytomegalovirus antiviral drug resistance. (Apr 2020)
    Maribavir 1.30 No resistance Laboratory strain, Clinical Isolate Recombinant Details Ganciclovir and maribavir cross-resistance revisited: Relative drug susceptibilities of canonical cytomegalovirus mutants. (Feb 2024)
    Ganciclovir 7.50 High level resistance Laboratory strain, Clinical Isolate Recombinant Details Ganciclovir and maribavir cross-resistance revisited: Relative drug susceptibilities of canonical cytomegalovirus mutants. (Feb 2024)

    Mutations at the same locus:

    Mutant Resistances
    595-603del Ganciclovir: High level resistance
    L595del Ganciclovir: High level resistance
    L595F Maribavir: No resistance
    L595F Ganciclovir: High level resistance
    L595W Maribavir: No resistance
    L595W Ganciclovir: High level resistance


    Tilloy et al., 2024
    Interdeposit Digital Number: IDDN.FR.001.420004.000.S.X.2024.000.31230